Abstract
In order to investigate nocturnal melatonin production and clearance rates, we applied deconvolution analysis to plasma melatonin concentration time series obtained every 20 min for 12 hr from 20:00 h to 08:00 h in two groups of healthy subjects at rest (group 1, 12 male subjects, 22-26 yr; group 2, ten female subjects, 31-42 yr). The estimated melatonin production rate from group 1 (0.55 ± 0.21 μg/kg/night) was significantly higher than that of group 2 (0.26 ± 0.19 μg/kg/night), as well as the mass of melatonin released per burst (275 ± 110 vs. 145 ± 130 pg/mL for groups 1 and 2, respectively), the amplitude of secretory bursts (7.8 ± 3.2 vs. 4.7 ± 3.5 pg/mL/min), and the pulsatile melatonin production rate (2.76 ± 1.14 vs. 1.27 ± 0.97 ng/mL/night). These differences could reflect alterations related to age and/or gender. No differences were observed between the two groups in the secretory burst half-duration and frequency and the interburst interval. Melatonin production rates, as estimated by deconvolution analysis, are in agreement with other independent estimates, especially the isotopic method, and disclose an ultradian rhythmicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-144 |
| Number of pages | 6 |
| Journal | Journal of Pineal Research |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1999 |
| Externally published | Yes |
Fingerprint
Keywords
- Episodic
- Humans
- Melatonin
- Secretion
- Ultradian
ASJC Scopus subject areas
- Endocrinology
Cite this
Estimation of frequently sampled nocturnal melatonin production in humans by deconvolution analysis : Evidence for episodic or ultradian secretion. / Geoffriau, Martine; Claustrat, Bruno; Veldhuis, Johannes D.
In: Journal of Pineal Research, Vol. 27, No. 3, 1999, p. 139-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estimation of frequently sampled nocturnal melatonin production in humans by deconvolution analysis
T2 - Evidence for episodic or ultradian secretion
AU - Geoffriau, Martine
AU - Claustrat, Bruno
AU - Veldhuis, Johannes D
PY - 1999
Y1 - 1999
N2 - In order to investigate nocturnal melatonin production and clearance rates, we applied deconvolution analysis to plasma melatonin concentration time series obtained every 20 min for 12 hr from 20:00 h to 08:00 h in two groups of healthy subjects at rest (group 1, 12 male subjects, 22-26 yr; group 2, ten female subjects, 31-42 yr). The estimated melatonin production rate from group 1 (0.55 ± 0.21 μg/kg/night) was significantly higher than that of group 2 (0.26 ± 0.19 μg/kg/night), as well as the mass of melatonin released per burst (275 ± 110 vs. 145 ± 130 pg/mL for groups 1 and 2, respectively), the amplitude of secretory bursts (7.8 ± 3.2 vs. 4.7 ± 3.5 pg/mL/min), and the pulsatile melatonin production rate (2.76 ± 1.14 vs. 1.27 ± 0.97 ng/mL/night). These differences could reflect alterations related to age and/or gender. No differences were observed between the two groups in the secretory burst half-duration and frequency and the interburst interval. Melatonin production rates, as estimated by deconvolution analysis, are in agreement with other independent estimates, especially the isotopic method, and disclose an ultradian rhythmicity.
AB - In order to investigate nocturnal melatonin production and clearance rates, we applied deconvolution analysis to plasma melatonin concentration time series obtained every 20 min for 12 hr from 20:00 h to 08:00 h in two groups of healthy subjects at rest (group 1, 12 male subjects, 22-26 yr; group 2, ten female subjects, 31-42 yr). The estimated melatonin production rate from group 1 (0.55 ± 0.21 μg/kg/night) was significantly higher than that of group 2 (0.26 ± 0.19 μg/kg/night), as well as the mass of melatonin released per burst (275 ± 110 vs. 145 ± 130 pg/mL for groups 1 and 2, respectively), the amplitude of secretory bursts (7.8 ± 3.2 vs. 4.7 ± 3.5 pg/mL/min), and the pulsatile melatonin production rate (2.76 ± 1.14 vs. 1.27 ± 0.97 ng/mL/night). These differences could reflect alterations related to age and/or gender. No differences were observed between the two groups in the secretory burst half-duration and frequency and the interburst interval. Melatonin production rates, as estimated by deconvolution analysis, are in agreement with other independent estimates, especially the isotopic method, and disclose an ultradian rhythmicity.
KW - Episodic
KW - Humans
KW - Melatonin
KW - Secretion
KW - Ultradian
UR - http://www.scopus.com/inward/record.url?scp=0032831958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032831958&partnerID=8YFLogxK
U2 - 10.1111/j.1600-079X.1999.tb00608.x
DO - 10.1111/j.1600-079X.1999.tb00608.x
M3 - Article
C2 - 10535762
AN - SCOPUS:0032831958
VL - 27
SP - 139
EP - 144
JO - Journal of Pineal Research
JF - Journal of Pineal Research
SN - 0742-3098
IS - 3
ER -