Estimating T1 from multichannel variable flip angle SPGR sequences

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Quantitative estimation of T1 is a challenging but important task inherent to many clinical applications. The most commonly used paradigm for estimating T1 in vivo involves performing a sequence of spoiled gradient-recalled echo acquisitions at different flip angles, followed by fitting of an exponential model to the data. Although there has been substantial work comparing different fitting methods, there has been little discussion on how these methods should be applied for data acquired using multichannel receivers. In this note, we demonstrate that the manner in which multichannel data is handled can have a substantial impact on T1 estimation performance and should be considered equally as important as choice of flip angles or fitting strategy.

Original languageEnglish (US)
Pages (from-to)1787-1794
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number6
StatePublished - Jun 2013


  • non-linear least squares
  • relaxometry
  • variable flip angle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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