TY - JOUR
T1 - Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression
AU - Rades, Dirk
AU - Conde-Moreno, Antonio J.
AU - Cacicedo, Jon
AU - Szegedin, Barbara
AU - Schild, Steven E.
N1 - Publisher Copyright:
Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001).CONCLUSION: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.
AB - AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001).CONCLUSION: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.
KW - Renal cell carcinoma
KW - elderly
KW - malignant spinal cord compression
KW - predictive tool
KW - survival
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M3 - Article
C2 - 26722074
AN - SCOPUS:84973409446
SN - 0250-7005
VL - 36
SP - 409
EP - 413
JO - Anticancer research
JF - Anticancer research
IS - 1
ER -