Estimated limits of IMRT dose escalation using varied planning target volume margins

Christopher C. Goulet, Michael G. Herman, David W. Hillman, Brian J. Davis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To estimate the limits of dose escalation for prostate cancer as a function of planning target volume (PTV) margins, the maximum achievable dose (MAD) was determined through iterative plan optimizations from data sets of 18 patients until the dose constraints for rectum, bladder and PTV could no longer be met. PTV margins of 10, 5 and 3 mm yielded a mean MAD of 83.0 Gy (range, 73.8-108.0 Gy), 113.1 Gy (range, 90.0-151.2 Gy) and 135.9 Gy (range, 102.6-189.0 Gy), respectively. All comparisons of MAD among margin groups were statistically significant (P < 0.001). Comparison of prostate volumes of 30-50 mL (n = 8) with volumes of 51-70 mL (n = 7) and 71-105 mL (n = 3) showed an inverse relationship with MAD. Decreases in PTV margin significantly decreased the PTV overlap of the rectum (P < 0.001 for all margin comparisons). With decreases in the PTV margin and maintenance of identical dose constraints, doses well above those currently prescribed for treatment of localized prostate cancer appear feasible. However, the dose escalation suggested by these findings is a theoretical estimate, and additional dose constraints will likely be necessary to limit toxicity to normal tissue.

Original languageEnglish (US)
Pages (from-to)3777-3788
Number of pages12
JournalPhysics in Medicine and Biology
Volume53
Issue number14
DOIs
StatePublished - Jul 21 2008

Fingerprint

Rectum
planning
margins
Prostatic Neoplasms
Planning
dosage
Prostate
Urinary Bladder
Maintenance
rectum
cancer
Toxicity
Therapeutics
Tissue
bladder
estimates
toxicity
maintenance
Datasets
optimization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy (miscellaneous)
  • Radiological and Ultrasound Technology

Cite this

Estimated limits of IMRT dose escalation using varied planning target volume margins. / Goulet, Christopher C.; Herman, Michael G.; Hillman, David W.; Davis, Brian J.

In: Physics in Medicine and Biology, Vol. 53, No. 14, 21.07.2008, p. 3777-3788.

Research output: Contribution to journalArticle

Goulet, Christopher C. ; Herman, Michael G. ; Hillman, David W. ; Davis, Brian J. / Estimated limits of IMRT dose escalation using varied planning target volume margins. In: Physics in Medicine and Biology. 2008 ; Vol. 53, No. 14. pp. 3777-3788.
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