Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis

John P. Marinelli, Jeffrey R. Janus, Jamie Van Gompel, Michael J. Link, Robert L. Foote, Christine M. Lohse, Katharine A. Price, Ashish Chintakuntlawar

Research output: Contribution to journalReview article

2 Scopus citations


Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods: We conducted a systematic review and meta-analysis. Results: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P <.001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P =.85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P <.001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P =.88). Conclusion: Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.

Original languageEnglish (US)
Pages (from-to)2295-2303
Number of pages9
JournalHead and Neck
Issue number10
StatePublished - Oct 1 2018



  • advanced disease
  • esthesioneuroblastoma
  • meta-analysis
  • metastatic
  • olfactory neuroblastoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Marinelli, J. P., Janus, J. R., Van Gompel, J., Link, M. J., Foote, R. L., Lohse, C. M., Price, K. A., & Chintakuntlawar, A. (2018). Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis. Head and Neck, 40(10), 2295-2303.