Esthesioneuroblastoma with distant metastases

Systematic review & meta-analysis

John P. Marinelli, Jeffrey R. Janus, Jamie Van Gompel, Michael J. Link, Robert L. Foote, Christine M. Lohse, Katharine A. Price, Ashish Chintakuntlawar

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods: We conducted a systematic review and meta-analysis. Results: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P <.001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P =.85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P <.001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P =.88). Conclusion: Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.

Original languageEnglish (US)
Pages (from-to)2295-2303
Number of pages9
JournalHead and Neck
Volume40
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

Olfactory Esthesioneuroblastoma
Meta-Analysis
Neoplasm Metastasis
Survival
Combination Drug Therapy
Radiation
Therapeutics
Platinum
Drug Therapy
Research

Keywords

  • advanced disease
  • esthesioneuroblastoma
  • meta-analysis
  • metastatic
  • olfactory neuroblastoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Esthesioneuroblastoma with distant metastases : Systematic review & meta-analysis. / Marinelli, John P.; Janus, Jeffrey R.; Van Gompel, Jamie; Link, Michael J.; Foote, Robert L.; Lohse, Christine M.; Price, Katharine A.; Chintakuntlawar, Ashish.

In: Head and Neck, Vol. 40, No. 10, 01.10.2018, p. 2295-2303.

Research output: Contribution to journalReview article

Marinelli, JP, Janus, JR, Van Gompel, J, Link, MJ, Foote, RL, Lohse, CM, Price, KA & Chintakuntlawar, A 2018, 'Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis', Head and Neck, vol. 40, no. 10, pp. 2295-2303. https://doi.org/10.1002/hed.25209
Marinelli, John P. ; Janus, Jeffrey R. ; Van Gompel, Jamie ; Link, Michael J. ; Foote, Robert L. ; Lohse, Christine M. ; Price, Katharine A. ; Chintakuntlawar, Ashish. / Esthesioneuroblastoma with distant metastases : Systematic review & meta-analysis. In: Head and Neck. 2018 ; Vol. 40, No. 10. pp. 2295-2303.
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