Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis

John P. Marinelli; Jeffrey R. Janus; Jamie J. Van Gompel; Michael J. Link; Robert L. Foote; Christine M. Lohse; Katharine A. Price; Ashish V. Chintakuntlawar

doi:10.1002/hed.25209

Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis

John P. Marinelli, Jeffrey R. Janus, Jamie J. Van Gompel, Michael J. Link, Robert L. Foote, Christine M. Lohse, Katharine A. Price, Ashish V. Chintakuntlawar

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods: We conducted a systematic review and meta-analysis. Results: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P <.001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P =.85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P <.001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P =.88). Conclusion: Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.

Original language	English (US)
Pages (from-to)	2295-2303
Number of pages	9
Journal	Head and Neck
Volume	40
Issue number	10
DOIs	https://doi.org/10.1002/hed.25209
State	Published - Oct 2018

Keywords

advanced disease
esthesioneuroblastoma
meta-analysis
metastatic
olfactory neuroblastoma

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.25209

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title = "Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis",

abstract = "Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods: We conducted a systematic review and meta-analysis. Results: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P <.001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P =.85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P <.001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P =.88). Conclusion: Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.",

keywords = "advanced disease, esthesioneuroblastoma, meta-analysis, metastatic, olfactory neuroblastoma",

author = "Marinelli, {John P.} and Janus, {Jeffrey R.} and {Van Gompel}, {Jamie J.} and Link, {Michael J.} and Foote, {Robert L.} and Lohse, {Christine M.} and Price, {Katharine A.} and Chintakuntlawar, {Ashish V.}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

month = oct,

doi = "10.1002/hed.25209",

language = "English (US)",

volume = "40",

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T2 - Systematic review & meta-analysis

AU - Marinelli, John P.

AU - Janus, Jeffrey R.

AU - Van Gompel, Jamie J.

AU - Link, Michael J.

AU - Foote, Robert L.

AU - Lohse, Christine M.

AU - Price, Katharine A.

AU - Chintakuntlawar, Ashish V.

PY - 2018/10

Y1 - 2018/10

N2 - Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods: We conducted a systematic review and meta-analysis. Results: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P <.001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P =.85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P <.001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P =.88). Conclusion: Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.

AB - Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods: We conducted a systematic review and meta-analysis. Results: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P <.001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P =.85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P <.001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P =.88). Conclusion: Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.

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KW - olfactory neuroblastoma

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Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis

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