Establishment of carrier-state infection of a feline renal cell line with feline syncytial virus

Takayuki Miyazawa, Shin ichi Itagaki, Keizo Tomonaga, Yasuhiro Ikeda, Takeshi Mori, Yasushi Kawaguchi, Tsuyoshi Gemma, Yukinobu Tohya, Takeshi Mikami, Masami Mochizuki

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Although feline syncytial virus (FSV) is normally highly cytopathogenic in Crandell feline kidney cells, a non-cytopathic persistent infection was established in the cells after cocultivation of the initially infected cells with uninfected cells 4 times. More than 90% of the persistentiy infected cells were positive for FSV antigen, and electron microscopy showed that the culture produced morphologically normal FSV. Virus from the carrier culture was infectious, however, the titer of the virus from the culture was lower than that from the cytocidally infected CRFK cells.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalJournal of Veterinary Medical Science
Volume57
Issue number1
DOIs
StatePublished - 1995

Keywords

  • CRFK cell
  • carrier culture
  • feline syncytial virus
  • spumavirus

ASJC Scopus subject areas

  • veterinary(all)

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