Establishment of a Pediatric Ovarian and Testicular Cryopreservation Program for Malignant and Non-Malignant Conditions: The Mayo Clinic Experience

Vidhu B. Joshi, Supriya Behl, Siobhan T. Pittock, Carola A.S. Arndt, Yulian Zhao, Zaraq Khan, Candace F. Granberg, Asma Chattha

Research output: Contribution to journalArticlepeer-review

Abstract

Study Objectives: To describe the structure of a pediatric fertility preservation (FP) program and to share safety and patient satisfaction data. Design: The FP program operates under prospective research protocols approved by the Mayo Clinic Institutional Review Board (IRB). Setting: The FP program is a multidisciplinary effort between pediatric gynecology, reproductive endocrinology, pediatric urology, pediatric surgery, and laboratory medicine. Participants: The FP program enrolls patients between 0-17 years of age who have been diagnosed with a fertility-threatening condition and/or are scheduled to undergo gonadotoxic treatment. Interventions: FP is offered in the form of ovarian tissue cryopreservation (OTC) and testicular (TTC) tissue cryopreservation. Main Outcome Measures: The outcome measures are the safety of the procedure and results of patient surveys conducted by phone using a standard list of questions to assess attitudes towards FP. Results: To date, we have enrolled 38 OTC and 37 TTC patients. The median age (range) of OTC and TTC patients was 11 years (0.83-17 years) and 10 years (0.92-17 years) at the time of enrollment, respectively. Childhood cancers currently represent 88% of the fertility-threatening diagnoses. Meanwhile, patients with non-malignant conditions include those with gender dysphoria, aplastic anemia, and Turner's syndrome. To date, no serious adverse events (SAEs) have been reported following surgery. According to n = 34 one-year follow-ups, 100% of parents felt that FP was a good decision. Conclusion: Consistent with the literature, our data suggests FP is safe and improves the quality of care provided to pediatric patients for their fertility-threatening diagnoses and/or treatments. Trial Registration: NCT02872532, NCT02646384.

Original languageEnglish (US)
Pages (from-to)673-680
Number of pages8
JournalJournal of Pediatric and Adolescent Gynecology
Volume34
Issue number5
DOIs
StateAccepted/In press - 2021

Keywords

  • Cancer survivorship
  • Childhood cancer
  • Fertility preservation
  • Infertility
  • Oncofertility
  • Transgender

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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