Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line

Hector Alvarez, Jan Bart M Koorstra, Seung Mo Hong, Jurjen J. Boonstra, Winand N M Dinjens, Arlene A. Foratiere, Tsung Teh Wu, Elizabeth Montgomery, James R. Eshleman, Anirban Maitra

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Esophageal adenocarcinoma currently has one of the most rapidly increasing tumor incidences in the United States, with the vast majority of cases occurring on the backdrop of metaplastic epithelium (Barrett esophagus). The availability of appropriate cell line models is essential for maintaining the pace of esophageal cancer research and for pre-clinical validation of new therapeutic modalities. The identity of several of the widely utilized esophageal adenocarcinoma cell lines (BIC-1, SEG-1 and TE-7) have recently been called into question. Here we describe the establishment and characterization of a bona fide esophageal cancer cell line, JH-EsoAd1, from a patient with Barrett-associated adenocarcinoma. The rapid dissemination of this cancer cell line to the esophageal cancer research community should help ameliorate the current scarcity of preclinical models in this disease.

Original languageEnglish (US)
Pages (from-to)1753-1755
Number of pages3
JournalCancer Biology and Therapy
Volume7
Issue number11
StatePublished - Nov 2008

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Barrett Esophagus
Adenocarcinoma
Esophageal Neoplasms
Cell Line
imidazole mustard
Research
Neoplasms
Epithelium
Incidence
Therapeutics

Keywords

  • Adenocarcinoma
  • Barrett esophagus
  • Cell line
  • Genotyping
  • JH-EsoAd1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine
  • Pharmacology

Cite this

Alvarez, H., Koorstra, J. B. M., Hong, S. M., Boonstra, J. J., Dinjens, W. N. M., Foratiere, A. A., ... Maitra, A. (2008). Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line. Cancer Biology and Therapy, 7(11), 1753-1755.

Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line. / Alvarez, Hector; Koorstra, Jan Bart M; Hong, Seung Mo; Boonstra, Jurjen J.; Dinjens, Winand N M; Foratiere, Arlene A.; Wu, Tsung Teh; Montgomery, Elizabeth; Eshleman, James R.; Maitra, Anirban.

In: Cancer Biology and Therapy, Vol. 7, No. 11, 11.2008, p. 1753-1755.

Research output: Contribution to journalArticle

Alvarez, H, Koorstra, JBM, Hong, SM, Boonstra, JJ, Dinjens, WNM, Foratiere, AA, Wu, TT, Montgomery, E, Eshleman, JR & Maitra, A 2008, 'Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line', Cancer Biology and Therapy, vol. 7, no. 11, pp. 1753-1755.
Alvarez H, Koorstra JBM, Hong SM, Boonstra JJ, Dinjens WNM, Foratiere AA et al. Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line. Cancer Biology and Therapy. 2008 Nov;7(11):1753-1755.
Alvarez, Hector ; Koorstra, Jan Bart M ; Hong, Seung Mo ; Boonstra, Jurjen J. ; Dinjens, Winand N M ; Foratiere, Arlene A. ; Wu, Tsung Teh ; Montgomery, Elizabeth ; Eshleman, James R. ; Maitra, Anirban. / Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell line. In: Cancer Biology and Therapy. 2008 ; Vol. 7, No. 11. pp. 1753-1755.
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