Establishing quality indicators for neck dissection: Correlating the number of lymph nodes with oncologic outcomes (NRG Oncology RTOG 9501 and RTOG 0234)

Vasu Divi, Jonathan Harris, Paul M. Harari, Jay S. Cooper, Jonathan McHugh, Diana Bell, Erich M. Sturgis, Anthony J. Cmelak, Mohan Suntharalingam, David Raben, Harold Kim, Sharon A. Spencer, George E. Laramore, Andy Trotti, Robert L. Foote, Christopher Schultz, Wade L. Thorstad, Qiang Ed Zhang, Quynh Thu Le, F. Christopher Holsinger

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

BACKGROUND: Prospective quality metrics for neck dissection have not been established for patients with head and neck squamous cell carcinoma. The purpose of this study was to investigate the association between lymph node counts from neck dissection, local-regional recurrence, and overall survival. METHODS: The number of lymph nodes counted from neck dissection in patients treated in 2 NRG Oncology trials (Radiation Therapy Oncology Group [RTOG] 9501 and RTOG 0234) was evaluated for its prognostic impact on overall survival with a multivariate Cox model adjusted for demographic, tumor, and lymph node data and stratified by the postoperative treatment group. RESULTS: Five hundred seventy-two patients were analyzed at a median follow-up of 8 years. Ninety-eight percent of the patients were pathologically N+. The median numbers of lymph nodes recorded on the left and right sides were 24 and 25, respectively. The identification of fewer than 18 nodes was associated with worse overall survival in comparison with 18 or more nodes (hazard ratio [HR], 1.38; 95% confidence interval [CI], 1.09-1.74; P =.007). The difference appeared to be driven by local-regional failure (HR, 1.46; 95% CI, 1.02-2.08; P =.04) but not by distant metastases (HR, 1.08; 95% CI, 0.77-1.53; P =.65). When the analysis was limited to NRG Oncology RTOG 0234 patients, adding the p16 status to the model did not affect the HR for dissected nodes, and the effect of nodes did not differ with the p16 status. CONCLUSIONS: The removal and identification of 18 or more lymph nodes was associated with improved overall survival and lower rates of local-regional failure, and this should be further evaluated as a measure of quality in neck dissections for mucosal squamous cell carcinoma. Cancer 2016;122:3464–71.

Original languageEnglish (US)
Pages (from-to)3464-3471
Number of pages8
JournalCancer
Volume122
Issue number22
DOIs
StatePublished - Nov 15 2016

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Radiation Oncology
Neck Dissection
Group Psychotherapy
Radiotherapy
Lymph Nodes
Confidence Intervals
Survival
Proportional Hazards Models
Squamous Cell Carcinoma
Neoplasms
Survival Rate
Demography
Neoplasm Metastasis
Recurrence

Keywords

  • head and neck cancer
  • neck dissection
  • quality indicators
  • surgery
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Establishing quality indicators for neck dissection : Correlating the number of lymph nodes with oncologic outcomes (NRG Oncology RTOG 9501 and RTOG 0234). / Divi, Vasu; Harris, Jonathan; Harari, Paul M.; Cooper, Jay S.; McHugh, Jonathan; Bell, Diana; Sturgis, Erich M.; Cmelak, Anthony J.; Suntharalingam, Mohan; Raben, David; Kim, Harold; Spencer, Sharon A.; Laramore, George E.; Trotti, Andy; Foote, Robert L.; Schultz, Christopher; Thorstad, Wade L.; Zhang, Qiang Ed; Le, Quynh Thu; Holsinger, F. Christopher.

In: Cancer, Vol. 122, No. 22, 15.11.2016, p. 3464-3471.

Research output: Contribution to journalArticle

Divi, V, Harris, J, Harari, PM, Cooper, JS, McHugh, J, Bell, D, Sturgis, EM, Cmelak, AJ, Suntharalingam, M, Raben, D, Kim, H, Spencer, SA, Laramore, GE, Trotti, A, Foote, RL, Schultz, C, Thorstad, WL, Zhang, QE, Le, QT & Holsinger, FC 2016, 'Establishing quality indicators for neck dissection: Correlating the number of lymph nodes with oncologic outcomes (NRG Oncology RTOG 9501 and RTOG 0234)', Cancer, vol. 122, no. 22, pp. 3464-3471. https://doi.org/10.1002/cncr.30204
Divi, Vasu ; Harris, Jonathan ; Harari, Paul M. ; Cooper, Jay S. ; McHugh, Jonathan ; Bell, Diana ; Sturgis, Erich M. ; Cmelak, Anthony J. ; Suntharalingam, Mohan ; Raben, David ; Kim, Harold ; Spencer, Sharon A. ; Laramore, George E. ; Trotti, Andy ; Foote, Robert L. ; Schultz, Christopher ; Thorstad, Wade L. ; Zhang, Qiang Ed ; Le, Quynh Thu ; Holsinger, F. Christopher. / Establishing quality indicators for neck dissection : Correlating the number of lymph nodes with oncologic outcomes (NRG Oncology RTOG 9501 and RTOG 0234). In: Cancer. 2016 ; Vol. 122, No. 22. pp. 3464-3471.
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abstract = "BACKGROUND: Prospective quality metrics for neck dissection have not been established for patients with head and neck squamous cell carcinoma. The purpose of this study was to investigate the association between lymph node counts from neck dissection, local-regional recurrence, and overall survival. METHODS: The number of lymph nodes counted from neck dissection in patients treated in 2 NRG Oncology trials (Radiation Therapy Oncology Group [RTOG] 9501 and RTOG 0234) was evaluated for its prognostic impact on overall survival with a multivariate Cox model adjusted for demographic, tumor, and lymph node data and stratified by the postoperative treatment group. RESULTS: Five hundred seventy-two patients were analyzed at a median follow-up of 8 years. Ninety-eight percent of the patients were pathologically N+. The median numbers of lymph nodes recorded on the left and right sides were 24 and 25, respectively. The identification of fewer than 18 nodes was associated with worse overall survival in comparison with 18 or more nodes (hazard ratio [HR], 1.38; 95{\%} confidence interval [CI], 1.09-1.74; P =.007). The difference appeared to be driven by local-regional failure (HR, 1.46; 95{\%} CI, 1.02-2.08; P =.04) but not by distant metastases (HR, 1.08; 95{\%} CI, 0.77-1.53; P =.65). When the analysis was limited to NRG Oncology RTOG 0234 patients, adding the p16 status to the model did not affect the HR for dissected nodes, and the effect of nodes did not differ with the p16 status. CONCLUSIONS: The removal and identification of 18 or more lymph nodes was associated with improved overall survival and lower rates of local-regional failure, and this should be further evaluated as a measure of quality in neck dissections for mucosal squamous cell carcinoma. Cancer 2016;122:3464–71.",
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T1 - Establishing quality indicators for neck dissection

T2 - Correlating the number of lymph nodes with oncologic outcomes (NRG Oncology RTOG 9501 and RTOG 0234)

AU - Divi, Vasu

AU - Harris, Jonathan

AU - Harari, Paul M.

AU - Cooper, Jay S.

AU - McHugh, Jonathan

AU - Bell, Diana

AU - Sturgis, Erich M.

AU - Cmelak, Anthony J.

AU - Suntharalingam, Mohan

AU - Raben, David

AU - Kim, Harold

AU - Spencer, Sharon A.

AU - Laramore, George E.

AU - Trotti, Andy

AU - Foote, Robert L.

AU - Schultz, Christopher

AU - Thorstad, Wade L.

AU - Zhang, Qiang Ed

AU - Le, Quynh Thu

AU - Holsinger, F. Christopher

PY - 2016/11/15

Y1 - 2016/11/15

N2 - BACKGROUND: Prospective quality metrics for neck dissection have not been established for patients with head and neck squamous cell carcinoma. The purpose of this study was to investigate the association between lymph node counts from neck dissection, local-regional recurrence, and overall survival. METHODS: The number of lymph nodes counted from neck dissection in patients treated in 2 NRG Oncology trials (Radiation Therapy Oncology Group [RTOG] 9501 and RTOG 0234) was evaluated for its prognostic impact on overall survival with a multivariate Cox model adjusted for demographic, tumor, and lymph node data and stratified by the postoperative treatment group. RESULTS: Five hundred seventy-two patients were analyzed at a median follow-up of 8 years. Ninety-eight percent of the patients were pathologically N+. The median numbers of lymph nodes recorded on the left and right sides were 24 and 25, respectively. The identification of fewer than 18 nodes was associated with worse overall survival in comparison with 18 or more nodes (hazard ratio [HR], 1.38; 95% confidence interval [CI], 1.09-1.74; P =.007). The difference appeared to be driven by local-regional failure (HR, 1.46; 95% CI, 1.02-2.08; P =.04) but not by distant metastases (HR, 1.08; 95% CI, 0.77-1.53; P =.65). When the analysis was limited to NRG Oncology RTOG 0234 patients, adding the p16 status to the model did not affect the HR for dissected nodes, and the effect of nodes did not differ with the p16 status. CONCLUSIONS: The removal and identification of 18 or more lymph nodes was associated with improved overall survival and lower rates of local-regional failure, and this should be further evaluated as a measure of quality in neck dissections for mucosal squamous cell carcinoma. Cancer 2016;122:3464–71.

AB - BACKGROUND: Prospective quality metrics for neck dissection have not been established for patients with head and neck squamous cell carcinoma. The purpose of this study was to investigate the association between lymph node counts from neck dissection, local-regional recurrence, and overall survival. METHODS: The number of lymph nodes counted from neck dissection in patients treated in 2 NRG Oncology trials (Radiation Therapy Oncology Group [RTOG] 9501 and RTOG 0234) was evaluated for its prognostic impact on overall survival with a multivariate Cox model adjusted for demographic, tumor, and lymph node data and stratified by the postoperative treatment group. RESULTS: Five hundred seventy-two patients were analyzed at a median follow-up of 8 years. Ninety-eight percent of the patients were pathologically N+. The median numbers of lymph nodes recorded on the left and right sides were 24 and 25, respectively. The identification of fewer than 18 nodes was associated with worse overall survival in comparison with 18 or more nodes (hazard ratio [HR], 1.38; 95% confidence interval [CI], 1.09-1.74; P =.007). The difference appeared to be driven by local-regional failure (HR, 1.46; 95% CI, 1.02-2.08; P =.04) but not by distant metastases (HR, 1.08; 95% CI, 0.77-1.53; P =.65). When the analysis was limited to NRG Oncology RTOG 0234 patients, adding the p16 status to the model did not affect the HR for dissected nodes, and the effect of nodes did not differ with the p16 status. CONCLUSIONS: The removal and identification of 18 or more lymph nodes was associated with improved overall survival and lower rates of local-regional failure, and this should be further evaluated as a measure of quality in neck dissections for mucosal squamous cell carcinoma. Cancer 2016;122:3464–71.

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