Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol

EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry, Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and purpose: An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out. We wished to estimate the effect of magnetic resonance image (MRI) spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry. Methods: Three expert tracers segmented twice the hippocampi of 10 ADNI subjects on MRI slices oriented perpendicular to the anterior-posterior commissure (AC-PC) line and the long hippocampal axes plane, following internationally harmonized landmarks. We computed intra and interrater reliability figures for total volumes and similarity coefficients. Results: Total volume reliability was similar for both orientations. Similarity coefficients were significantly higher for the AC-PC orientation (exact P = 0.002). Discussion: These data show that AC-PC orientation is slightly more reliable for manual segmentations, possibly due to better visualization of the cerebrospinal fluid spaces separating hippocampal head and amygdala. A Delphi panel of experts has used these data to decide on the optimal orientation for a Harmonized Protocol for hippocampal segmentation.

Original languageEnglish (US)
Pages (from-to)509-514
Number of pages6
JournalJournal of Neuroimaging
Volume24
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Magnetic Resonance Spectroscopy
Amygdala
Cerebrospinal Fluid
Hippocampus
Head

Keywords

  • Harmonized protocol
  • Hippocampus
  • Magnetic resonance imaging
  • Manual segmentation
  • Standard operating procedures

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry, & Alzheimer's Disease Neuroimaging Initiative (2014). Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol. Journal of Neuroimaging, 24(5), 509-514. https://doi.org/10.1111/jon.12065

Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol. / EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry; Alzheimer's Disease Neuroimaging Initiative.

In: Journal of Neuroimaging, Vol. 24, No. 5, 2014, p. 509-514.

Research output: Contribution to journalArticle

EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry & Alzheimer's Disease Neuroimaging Initiative 2014, 'Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol', Journal of Neuroimaging, vol. 24, no. 5, pp. 509-514. https://doi.org/10.1111/jon.12065
EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry, Alzheimer's Disease Neuroimaging Initiative. Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol. Journal of Neuroimaging. 2014;24(5):509-514. https://doi.org/10.1111/jon.12065
EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry ; Alzheimer's Disease Neuroimaging Initiative. / Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol. In: Journal of Neuroimaging. 2014 ; Vol. 24, No. 5. pp. 509-514.
@article{512dcfce08be40b0a1500cf4b4fde3bb,
title = "Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol",
abstract = "Background and purpose: An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out. We wished to estimate the effect of magnetic resonance image (MRI) spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry. Methods: Three expert tracers segmented twice the hippocampi of 10 ADNI subjects on MRI slices oriented perpendicular to the anterior-posterior commissure (AC-PC) line and the long hippocampal axes plane, following internationally harmonized landmarks. We computed intra and interrater reliability figures for total volumes and similarity coefficients. Results: Total volume reliability was similar for both orientations. Similarity coefficients were significantly higher for the AC-PC orientation (exact P = 0.002). Discussion: These data show that AC-PC orientation is slightly more reliable for manual segmentations, possibly due to better visualization of the cerebrospinal fluid spaces separating hippocampal head and amygdala. A Delphi panel of experts has used these data to decide on the optimal orientation for a Harmonized Protocol for hippocampal segmentation.",
keywords = "Harmonized protocol, Hippocampus, Magnetic resonance imaging, Manual segmentation, Standard operating procedures",
author = "{EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry} and {Alzheimer's Disease Neuroimaging Initiative} and Marina Boccardi and Martina Bocchetta and Apostolova, {Liana G.} and Gregory Preboske and Nicolas Robitaille and Patrizio Pasqualetti and Collins, {Louis D.} and Simon Duchesne and Jack, {Clifford R Jr.} and Frisoni, {Giovanni B.}",
year = "2014",
doi = "10.1111/jon.12065",
language = "English (US)",
volume = "24",
pages = "509--514",
journal = "Journal of Neuroimaging",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Establishing Magnetic Resonance Images Orientation for the EADC-ADNI Manual Hippocampal Segmentation Protocol

AU - EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry

AU - Alzheimer's Disease Neuroimaging Initiative

AU - Boccardi, Marina

AU - Bocchetta, Martina

AU - Apostolova, Liana G.

AU - Preboske, Gregory

AU - Robitaille, Nicolas

AU - Pasqualetti, Patrizio

AU - Collins, Louis D.

AU - Duchesne, Simon

AU - Jack, Clifford R Jr.

AU - Frisoni, Giovanni B.

PY - 2014

Y1 - 2014

N2 - Background and purpose: An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out. We wished to estimate the effect of magnetic resonance image (MRI) spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry. Methods: Three expert tracers segmented twice the hippocampi of 10 ADNI subjects on MRI slices oriented perpendicular to the anterior-posterior commissure (AC-PC) line and the long hippocampal axes plane, following internationally harmonized landmarks. We computed intra and interrater reliability figures for total volumes and similarity coefficients. Results: Total volume reliability was similar for both orientations. Similarity coefficients were significantly higher for the AC-PC orientation (exact P = 0.002). Discussion: These data show that AC-PC orientation is slightly more reliable for manual segmentations, possibly due to better visualization of the cerebrospinal fluid spaces separating hippocampal head and amygdala. A Delphi panel of experts has used these data to decide on the optimal orientation for a Harmonized Protocol for hippocampal segmentation.

AB - Background and purpose: An effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out. We wished to estimate the effect of magnetic resonance image (MRI) spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry. Methods: Three expert tracers segmented twice the hippocampi of 10 ADNI subjects on MRI slices oriented perpendicular to the anterior-posterior commissure (AC-PC) line and the long hippocampal axes plane, following internationally harmonized landmarks. We computed intra and interrater reliability figures for total volumes and similarity coefficients. Results: Total volume reliability was similar for both orientations. Similarity coefficients were significantly higher for the AC-PC orientation (exact P = 0.002). Discussion: These data show that AC-PC orientation is slightly more reliable for manual segmentations, possibly due to better visualization of the cerebrospinal fluid spaces separating hippocampal head and amygdala. A Delphi panel of experts has used these data to decide on the optimal orientation for a Harmonized Protocol for hippocampal segmentation.

KW - Harmonized protocol

KW - Hippocampus

KW - Magnetic resonance imaging

KW - Manual segmentation

KW - Standard operating procedures

UR - http://www.scopus.com/inward/record.url?scp=84908548696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908548696&partnerID=8YFLogxK

U2 - 10.1111/jon.12065

DO - 10.1111/jon.12065

M3 - Article

VL - 24

SP - 509

EP - 514

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

SN - 1051-2284

IS - 5

ER -