Established and potential therapeutic applications of octreotide in palliative care

Eric E. Prommer

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Octreotide acetate was developed as a pharmacologically stable, long-acting analogue of the hormone somatostatin. Mimicking the actions of somatostatin, octreotide has been used for its antisecretory effects. Randomized control trials have established the efficacy of octreotide for malignant bowel obstruction and for chemotherapy-induced diarrhea. Octreotide has proven to be an effective agent for symptoms of carcinoid syndrome. Newer uses include for bone marrow transplantation, infectious diarrheal syndromes, and management of hepatic metastases. More evidence is needed for the establishment of its efficacy for hypercalcemia, pain, pleural effusions, diarrhea after celiac plexus block, and malignant ascites.

Original languageEnglish (US)
Pages (from-to)1117-1123
Number of pages7
JournalSupportive Care in Cancer
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2008

Keywords

  • Bowel obstruction
  • Diarrhea
  • Somatostatin

ASJC Scopus subject areas

  • Oncology

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