Essential tremor: Phenotypic expression in a clinical cohort

N. R. Whaley, John D. Putzke, Yasuhiko Baba, Zbigniew K Wszolek, Ryan J. Uitti

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Objectives: Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria. Methods: A clinical series of 487 consecutive individuals diagnosed with ET were included for study. Results: The sample was 53% male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97%), voice (62%), and head or neck (48%). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET. Conclusion: The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalParkinsonism and Related Disorders
Volume13
Issue number6
DOIs
StatePublished - Aug 2007

Fingerprint

Essential Tremor
Tremor
Age of Onset
Arm
Neck
Head

Keywords

  • Clinical features
  • Essential tremor
  • Phenotype

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

Cite this

Essential tremor : Phenotypic expression in a clinical cohort. / Whaley, N. R.; Putzke, John D.; Baba, Yasuhiko; Wszolek, Zbigniew K; Uitti, Ryan J.

In: Parkinsonism and Related Disorders, Vol. 13, No. 6, 08.2007, p. 333-339.

Research output: Contribution to journalArticle

Whaley, N. R. ; Putzke, John D. ; Baba, Yasuhiko ; Wszolek, Zbigniew K ; Uitti, Ryan J. / Essential tremor : Phenotypic expression in a clinical cohort. In: Parkinsonism and Related Disorders. 2007 ; Vol. 13, No. 6. pp. 333-339.
@article{b0f6d73383904ec799a11e554813638f,
title = "Essential tremor: Phenotypic expression in a clinical cohort",
abstract = "Objectives: Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria. Methods: A clinical series of 487 consecutive individuals diagnosed with ET were included for study. Results: The sample was 53{\%} male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97{\%}), voice (62{\%}), and head or neck (48{\%}). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET. Conclusion: The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.",
keywords = "Clinical features, Essential tremor, Phenotype",
author = "Whaley, {N. R.} and Putzke, {John D.} and Yasuhiko Baba and Wszolek, {Zbigniew K} and Uitti, {Ryan J.}",
year = "2007",
month = "8",
doi = "10.1016/j.parkreldis.2006.12.004",
language = "English (US)",
volume = "13",
pages = "333--339",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - Essential tremor

T2 - Phenotypic expression in a clinical cohort

AU - Whaley, N. R.

AU - Putzke, John D.

AU - Baba, Yasuhiko

AU - Wszolek, Zbigniew K

AU - Uitti, Ryan J.

PY - 2007/8

Y1 - 2007/8

N2 - Objectives: Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria. Methods: A clinical series of 487 consecutive individuals diagnosed with ET were included for study. Results: The sample was 53% male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97%), voice (62%), and head or neck (48%). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET. Conclusion: The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.

AB - Objectives: Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria. Methods: A clinical series of 487 consecutive individuals diagnosed with ET were included for study. Results: The sample was 53% male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97%), voice (62%), and head or neck (48%). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET. Conclusion: The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.

KW - Clinical features

KW - Essential tremor

KW - Phenotype

UR - http://www.scopus.com/inward/record.url?scp=34547683269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547683269&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2006.12.004

DO - 10.1016/j.parkreldis.2006.12.004

M3 - Article

C2 - 17291815

AN - SCOPUS:34547683269

VL - 13

SP - 333

EP - 339

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

IS - 6

ER -