@article{430084472d7d40ea98e6aa1a6d0fecbc,
title = "Essential Tremor and Depression",
abstract = "Introduction: Depression and neuropsychiatric disorders in individuals with essential tremor (ET) are not well characterized in the literature. Methods: We compared 104 ET subjects with 481 non-ET controls involved in the Arizona Study of Aging and Neurodegenerative Disorders. An analysis of baseline depression scales and neuropsychiatric inventory (NPI) was done between the two groups. Additionally, comparisons were made within the ET group based on tremor severity, duration of tremor, and age of onset. Results: There were no significant differences between the ET and non-ET groups. There were no significant differences in the ET group above and below the median tremor duration. Additionally, no differences were found in the ET group based on objective measures of tremor severity, age of onset, or those with subjectively distressing tremor compared with those without. Conclusion: There were no significant differences in depressive symptoms between ET and non-ET groups. Furthermore, no correlation was found between depressive symptoms in ET groups based on tremor severity, duration, or age of onset.",
keywords = "cognitive, depression, essential tremor, tremor",
author = "Sana Aslam and Nan Zhang and Adler, {Charles H.} and Caviness, {John N.} and Erika Driver-Dunckley and Mehta, {Shyamal H.} and Sabbagh, {Marwan N.} and Christine Belden and Edward Zamrini and Beach, {Thomas G.} and Shill, {Holly A.}",
note = "Funding Information: has no disclosures. Ms. Zhang has no disclosures. Dr. Adler has received consulting fees from Acadia, Adamas, Cynapsus, Impax, Ipsen, Jazz, Lundbeck, Merz, and Neurocrine. Dr. Caviness has received grants from The Michael J. Fox Foundation for Parkinson{\textquoteright}s disease research. Dr. Driver-Dunckley has received research support from Ipsen, EMD Sereno, Abbvie, BMS, and The Michael J Fox Foundation. Dr. Mehta has received research grants for clinical trials from Acorda Therapeutics, Cynapsus Inc., US WorldMeds, and is an investigator for SURE PD3 through the Parkinson{\textquoteright}s Study Group. Dr. Sabbagh has consulted for Axo-vant, Biogen, Grifols, Humana, Lilly Pharmaceuticals, Sanofi, and vTv Therapeutics. He has received research grants from AstraZe-neca, Avid Pharmaceuticals, Axovant, Genentech, Inc., Lilly Pharmaceuticals, Merek & Co, Pfizer, Roche Diagnostics Corporation, vTv Therapeutics, and Piramal Imaging. He is a stock shareholder in Brain Health, Muses Labs, and Versanum. Dr. Bel-den receives clinical trial funding support from AbbVie, Neu-ronix, Astra Zeneca, Novartis, Avanir, Avid, Axovant, Biogen, Genentech, IntraCellular, Lilly, Merck, Roche, Suven, Takeda, and inVentiv Health; also, Arizona Alzheimer{\textquoteright}s Consortium, Sun Health Foundation, NIH, and CMS. Dr. Zamrini receives clinical trial funding support from AbbVie, Acadia, Neuronix, Astra Zeneca, Novartis, Avanir, Avid, Axovant, Biogen, Genentech, IntraCellular, Lilly, Merck, Otsuka, Roche, Suven, Takeda, NeuroEM, and inVentiv Health; also, Arizona Alzheimer{\textquoteright}s Consortium, Sun Health Foundation, NIH, and CMS. Dr. Beach has served on an advisory boards for Genentech and consultant for GE Healthcare and Avid Radiopharmaceuticals. He has research support from Avid Radiopharmaceuticals, Navidea Biopharma-ceuticals, The Michael J Fox Foundation, NIH, and the Arizona Department of Health and Human Services. Dr. Shill has served as a consultant with Cynapsus/Sunovion, Abbvie, and Lundbeck. Dr. Shill has received research support from Cynapsus/Sunovion, Axovant, Impax, US World Meds, The Michael J. Fox Foundation, and the NIH. Ethical Compliance Statement: We confirm that we have read the Journal{\textquoteright}s position on issues involved in ethical publication and affirm that this work is consistent with those guidelines. Funding Information: Study of Aging and Neurodegenerative Disorders is supported by the National Institute of Neurological Disorders and Stroke (U24 NS072026 National Brain and Tissue Resource for Parkinson{\textquoteright}s Disease and Related Disorders), the National Institute on Aging (P30 AG19610 Arizona Alzheimer{\textquoteright}s Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer{\textquoteright}s Research Center), the Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901, and 1001 to the Arizona Parkinson{\textquoteright}s Disease Consortium), The Michael J. Fox Foundation for Parkinson{\textquoteright}s Research, the Mayo Clinic Foundation, Sun Health Foundation, Bob and Renee Parsons Foundation, and the International Essential Tremor Foundation. The authors declare that there are no conflicts of interest relevant to this work. Funding Information: We are grateful to the subjects who have volunteered to participate in the Banner Sun Health Research Institute Brain and Body Donation Program. The authors thank Mr. Bruce Peterson for developing and maintaining the database. Publisher Copyright: {\textcopyright} 2017 International Parkinson and Movement Disorder Society",
year = "2017",
month = nov,
day = "1",
doi = "10.1002/mdc3.12530",
language = "English (US)",
volume = "4",
pages = "838--842",
journal = "Movement Disorders Clinical Practice",
issn = "2330-1619",
publisher = "John Wiley and Sons Ltd",
number = "6",
}