Essential roles for the non-canonical iκb kinases in linking inflammation to cancer, obesity, and diabetes

Chong Hyun Shin; Doo Sup Choi

doi:10.3390/cells8020178

Essential roles for the non-canonical iκb kinases in linking inflammation to cancer, obesity, and diabetes

Chong Hyun Shin, Doo Sup Choi

Pharmacology

Research output: Contribution to journal › Review article › peer-review

Abstract

Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of innate immunity and cancer. Recent work has also implicated these kinases in distinctively controlling glucose homeostasis and repressing adaptive thermogenic and mitochondrial biogenic response upon obesity-induced inflammation. Additionally, TBK1 and IKKε regulate pancreatic β-cell regeneration. In this review, we summarize current data on the functions and molecular mechanisms of TBK1 and IKKε in orchestrating inflammation to cancer, obesity, and diabetes.

Original language	English (US)
Article number	178
Journal	Cells
Volume	8
Issue number	2
DOIs	https://doi.org/10.3390/cells8020178
State	Published - Feb 2019

Keywords

Cancer
Diabetes
IKKε
Inflammation
Metabolic disease
Obesity
TBK1

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells8020178

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abstract = "Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of innate immunity and cancer. Recent work has also implicated these kinases in distinctively controlling glucose homeostasis and repressing adaptive thermogenic and mitochondrial biogenic response upon obesity-induced inflammation. Additionally, TBK1 and IKKε regulate pancreatic β-cell regeneration. In this review, we summarize current data on the functions and molecular mechanisms of TBK1 and IKKε in orchestrating inflammation to cancer, obesity, and diabetes.",

keywords = "Cancer, Diabetes, IKKε, Inflammation, Metabolic disease, Obesity, TBK1",

author = "Shin, {Chong Hyun} and Choi, {Doo Sup}",

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AB - Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of innate immunity and cancer. Recent work has also implicated these kinases in distinctively controlling glucose homeostasis and repressing adaptive thermogenic and mitochondrial biogenic response upon obesity-induced inflammation. Additionally, TBK1 and IKKε regulate pancreatic β-cell regeneration. In this review, we summarize current data on the functions and molecular mechanisms of TBK1 and IKKε in orchestrating inflammation to cancer, obesity, and diabetes.

KW - Cancer

KW - Diabetes

KW - IKKε

KW - Inflammation

KW - Metabolic disease

KW - Obesity

KW - TBK1

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Essential roles for the non-canonical iκb kinases in linking inflammation to cancer, obesity, and diabetes

Abstract

Keywords

ASJC Scopus subject areas

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