Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration

Yonghe Li, Wenyan Lu, Guojun Bu

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The low density lipoprotein receptor-related protein (LRP) is a multifunctional cell surface receptor highly expressed in human aortic smooth muscle cells. In the present study, we used the short interfering RNA (siRNA) technique to explore the role of LRP in smooth muscle cell migration. We identified an LRP-specific siRNA that selective silences LRP expression in human aortic smooth muscle cells. As a consequence, LRP-mediated ligand degradation was significantly reduced. More important, we found that platelet-derived growth factor-dependent cell migration was inhibited in cells transfected with LRP siRNA. These results demonstrate an important role of LRP in smooth muscle cell migration.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalFEBS Letters
Volume555
Issue number2
DOIs
StatePublished - Dec 4 2003

Keywords

  • Cell migration
  • Ligand degradation
  • Low density lipoprotein receptor-related protein
  • Short interfering RNA
  • Smooth muscle cell

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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