Esophageal Epidermoid Metaplasia: Clinical Characteristics and Risk of Esophageal Squamous Neoplasia

Amrit K. Kamboj, Ying Y. Gibbens, Catherine E. Hagen, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: Esophageal epidermoid metaplasia (EEM) is a rare disease. METHODS: Patients with EEM diagnosed between 2014 and 2020 were reviewed. RESULTS: Forty EEM cases were identified. EEM occurred in 9 (23%) patients before, concordant, or after esophageal squamous cell carcinoma (ESCC). EEM was associated with previous esophageal lichen planus in 5 patients, Barrett's esophagus 7, and esophageal adenocarcinoma 1. EEM was focal in 28 (70%) or diffuse in 12 (30%) and not detected in 45% on recent previous endoscopy. DISCUSSION: EEM is a premalignant underrecognized condition associated with multiple conditions. Close follow-up or endoscopic treatment may be warranted because of its ESCC association.

Original languageEnglish (US)
Pages (from-to)1533-1536
Number of pages4
JournalThe American Journal of Gastroenterology
Volume116
Issue number7
DOIs
StatePublished - Jul 1 2021

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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