Esophageal cancer and Barrett's esophagus: How to approach surveillance, treatment, and palliation

Wael Shahin, Joseph A Murray

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Esophageal cancer is an increasingly common problem with poor survival rates in patients who present with symptoms. The underlying cause for the progressive rise in the incidence of this cancer remains to be determined. Reducing mortality requires either early identification of patients or prevention of progression from Barrett's esophagus to cancer. Significant questions remain regarding the cost-effectiveness of endoscopic and nonendoscopic methods of surveillance. For local esophageal cancer, the traditional approach has been surgical resection. Radiation therapy is sometimes used alone, but chemotherapy alone is not helpful. Combination therapy consisting of chemotherapy along with surgery or radiation may be the best choice. A new option being tried in disease limited to the mucosa is ablation of neoplastic tissue with endoscopic techniques. Treatment of advanced-stage esophageal cancer is limited and may be hampered by the presence of micrometastatic disease. Morbidity and quality-of-life issues need to be considered and discussed with patients, given the current short survival time of most patients with esophageal cancer.

Original languageEnglish (US)
Pages (from-to)111-127
Number of pages17
JournalPostgraduate Medicine
Volume105
Issue number7
StatePublished - 1999

Fingerprint

Barrett Esophagus
Esophageal Neoplasms
Therapeutics
Drug Therapy
Cost-Benefit Analysis
Mucous Membrane
Radiotherapy
Survival Rate
Quality of Life
Radiation
Morbidity
Survival
Mortality
Incidence
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Esophageal cancer and Barrett's esophagus : How to approach surveillance, treatment, and palliation. / Shahin, Wael; Murray, Joseph A.

In: Postgraduate Medicine, Vol. 105, No. 7, 1999, p. 111-127.

Research output: Contribution to journalArticle

@article{b8faa3da0ade44b28db1dab1f1dc2399,
title = "Esophageal cancer and Barrett's esophagus: How to approach surveillance, treatment, and palliation",
abstract = "Esophageal cancer is an increasingly common problem with poor survival rates in patients who present with symptoms. The underlying cause for the progressive rise in the incidence of this cancer remains to be determined. Reducing mortality requires either early identification of patients or prevention of progression from Barrett's esophagus to cancer. Significant questions remain regarding the cost-effectiveness of endoscopic and nonendoscopic methods of surveillance. For local esophageal cancer, the traditional approach has been surgical resection. Radiation therapy is sometimes used alone, but chemotherapy alone is not helpful. Combination therapy consisting of chemotherapy along with surgery or radiation may be the best choice. A new option being tried in disease limited to the mucosa is ablation of neoplastic tissue with endoscopic techniques. Treatment of advanced-stage esophageal cancer is limited and may be hampered by the presence of micrometastatic disease. Morbidity and quality-of-life issues need to be considered and discussed with patients, given the current short survival time of most patients with esophageal cancer.",
author = "Wael Shahin and Murray, {Joseph A}",
year = "1999",
language = "English (US)",
volume = "105",
pages = "111--127",
journal = "Postgraduate Medicine",
issn = "0032-5481",
publisher = "Medquest Communications LLC",
number = "7",

}

TY - JOUR

T1 - Esophageal cancer and Barrett's esophagus

T2 - How to approach surveillance, treatment, and palliation

AU - Shahin, Wael

AU - Murray, Joseph A

PY - 1999

Y1 - 1999

N2 - Esophageal cancer is an increasingly common problem with poor survival rates in patients who present with symptoms. The underlying cause for the progressive rise in the incidence of this cancer remains to be determined. Reducing mortality requires either early identification of patients or prevention of progression from Barrett's esophagus to cancer. Significant questions remain regarding the cost-effectiveness of endoscopic and nonendoscopic methods of surveillance. For local esophageal cancer, the traditional approach has been surgical resection. Radiation therapy is sometimes used alone, but chemotherapy alone is not helpful. Combination therapy consisting of chemotherapy along with surgery or radiation may be the best choice. A new option being tried in disease limited to the mucosa is ablation of neoplastic tissue with endoscopic techniques. Treatment of advanced-stage esophageal cancer is limited and may be hampered by the presence of micrometastatic disease. Morbidity and quality-of-life issues need to be considered and discussed with patients, given the current short survival time of most patients with esophageal cancer.

AB - Esophageal cancer is an increasingly common problem with poor survival rates in patients who present with symptoms. The underlying cause for the progressive rise in the incidence of this cancer remains to be determined. Reducing mortality requires either early identification of patients or prevention of progression from Barrett's esophagus to cancer. Significant questions remain regarding the cost-effectiveness of endoscopic and nonendoscopic methods of surveillance. For local esophageal cancer, the traditional approach has been surgical resection. Radiation therapy is sometimes used alone, but chemotherapy alone is not helpful. Combination therapy consisting of chemotherapy along with surgery or radiation may be the best choice. A new option being tried in disease limited to the mucosa is ablation of neoplastic tissue with endoscopic techniques. Treatment of advanced-stage esophageal cancer is limited and may be hampered by the presence of micrometastatic disease. Morbidity and quality-of-life issues need to be considered and discussed with patients, given the current short survival time of most patients with esophageal cancer.

UR - http://www.scopus.com/inward/record.url?scp=0033067932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033067932&partnerID=8YFLogxK

M3 - Article

C2 - 10376054

AN - SCOPUS:0033067932

VL - 105

SP - 111

EP - 127

JO - Postgraduate Medicine

JF - Postgraduate Medicine

SN - 0032-5481

IS - 7

ER -