ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

Eric Van Cutsem; A. Cervantes; R. Adam; A. Sobrero; J. H. Van Krieken; D. Aderka; E. Aranda Aguilar; A. Bardelli; A. Benson; G. Bodoky; F. Ciardiello; A. D'Hoore; E. Diaz-Rubio; J. Y. Douillard; M. Ducreux; A. Falcone; A. Grothey; T. Gruenberger; K. Haustermans; V. Heinemann; P. Hoff; C. H. Köhne; R. Labianca; P. Laurent-Puig; B. Ma; T. Maughan; K. Muro; N. Normanno; P. österlund; W. J.G. Oyen; D. Papamichael; G. Pentheroudakis; P. Pfeiffer; T. J. Price; C. Punt; J. Ricke; A. Roth; R. Salazar; W. Scheithauer; H. J. Schmoll; J. Tabernero; J. Taïeb; S. Tejpar; H. Wasan; T. Yoshino; A. Zaanan; D. Arnold

doi:10.1093/annonc/mdw235

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

Eric Van Cutsem, A. Cervantes, R. Adam, A. Sobrero, J. H. Van Krieken, D. Aderka, E. Aranda Aguilar, A. Bardelli, A. Benson, G. Bodoky, F. Ciardiello, A. D'Hoore, E. Diaz-Rubio, J. Y. Douillard, M. Ducreux, A. Falcone, A. Grothey, T. Gruenberger, K. Haustermans, V. HeinemannP. Hoff, C. H. Köhne, R. Labianca, P. Laurent-Puig, B. Ma, T. Maughan, K. Muro, N. Normanno, P. österlund, W. J.G. Oyen, D. Papamichael, G. Pentheroudakis, P. Pfeiffer, T. J. Price, C. Punt, J. Ricke, A. Roth, R. Salazar, W. Scheithauer, H. J. Schmoll, J. Tabernero, J. Taïeb, S. Tejpar, H. Wasan, T. Yoshino, A. Zaanan, D. Arnold

Medical Oncology

Research output: Contribution to journal › Article › peer-review

1367 Scopus citations

Abstract

Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.

Original language	English (US)
Pages (from-to)	1386-1422
Number of pages	37
Journal	Annals of Oncology
Volume	27
Issue number	8
DOIs	https://doi.org/10.1093/annonc/mdw235
State	Published - Aug 1 2016

Keywords

Clinical practice guidelines
Colorectal cancer
Consensus
ESMO

ASJC Scopus subject areas

Hematology
Oncology

Access to Document

10.1093/annonc/mdw235

Cite this

Van Cutsem, E., Cervantes, A., Adam, R., Sobrero, A., Van Krieken, J. H., Aderka, D., Aranda Aguilar, E., Bardelli, A., Benson, A., Bodoky, G., Ciardiello, F., D'Hoore, A., Diaz-Rubio, E., Douillard, J. Y., Ducreux, M., Falcone, A., Grothey, A., Gruenberger, T., Haustermans, K., ... Arnold, D. (2016). ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Annals of Oncology, 27(8), 1386-1422. https://doi.org/10.1093/annonc/mdw235

Van Cutsem, E, Cervantes, A, Adam, R, Sobrero, A, Van Krieken, JH, Aderka, D, Aranda Aguilar, E, Bardelli, A, Benson, A, Bodoky, G, Ciardiello, F, D'Hoore, A, Diaz-Rubio, E, Douillard, JY, Ducreux, M, Falcone, A, Grothey, A, Gruenberger, T, Haustermans, K, Heinemann, V, Hoff, P, Köhne, CH, Labianca, R, Laurent-Puig, P, Ma, B, Maughan, T, Muro, K, Normanno, N, österlund, P, Oyen, WJG, Papamichael, D, Pentheroudakis, G, Pfeiffer, P, Price, TJ, Punt, C, Ricke, J, Roth, A, Salazar, R, Scheithauer, W, Schmoll, HJ, Tabernero, J, Taïeb, J, Tejpar, S, Wasan, H, Yoshino, T, Zaanan, A & Arnold, D 2016, 'ESMO consensus guidelines for the management of patients with metastatic colorectal cancer', Annals of Oncology, vol. 27, no. 8, pp. 1386-1422. https://doi.org/10.1093/annonc/mdw235

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title = "ESMO consensus guidelines for the management of patients with metastatic colorectal cancer",

abstract = "Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.",

keywords = "Clinical practice guidelines, Colorectal cancer, Consensus, ESMO",

author = "{Van Cutsem}, Eric and A. Cervantes and R. Adam and A. Sobrero and {Van Krieken}, {J. H.} and D. Aderka and {Aranda Aguilar}, E. and A. Bardelli and A. Benson and G. Bodoky and F. Ciardiello and A. D'Hoore and E. Diaz-Rubio and Douillard, {J. Y.} and M. Ducreux and A. Falcone and A. Grothey and T. Gruenberger and K. Haustermans and V. Heinemann and P. Hoff and K{\"o}hne, {C. H.} and R. Labianca and P. Laurent-Puig and B. Ma and T. Maughan and K. Muro and N. Normanno and P. {\"o}sterlund and Oyen, {W. J.G.} and D. Papamichael and G. Pentheroudakis and P. Pfeiffer and Price, {T. J.} and C. Punt and J. Ricke and A. Roth and R. Salazar and W. Scheithauer and Schmoll, {H. J.} and J. Tabernero and J. Ta{\"i}eb and S. Tejpar and H. Wasan and T. Yoshino and A. Zaanan and D. Arnold",

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T1 - ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

AU - Van Cutsem, Eric

AU - Cervantes, A.

AU - Adam, R.

AU - Sobrero, A.

AU - Van Krieken, J. H.

AU - Aderka, D.

AU - Aranda Aguilar, E.

AU - Bardelli, A.

AU - Benson, A.

AU - Bodoky, G.

AU - Ciardiello, F.

AU - D'Hoore, A.

AU - Diaz-Rubio, E.

AU - Douillard, J. Y.

AU - Ducreux, M.

AU - Falcone, A.

AU - Grothey, A.

AU - Gruenberger, T.

AU - Haustermans, K.

AU - Heinemann, V.

AU - Hoff, P.

AU - Köhne, C. H.

AU - Labianca, R.

AU - Laurent-Puig, P.

AU - Ma, B.

AU - Maughan, T.

AU - Muro, K.

AU - Normanno, N.

AU - österlund, P.

AU - Oyen, W. J.G.

AU - Papamichael, D.

AU - Pentheroudakis, G.

AU - Pfeiffer, P.

AU - Price, T. J.

AU - Punt, C.

AU - Ricke, J.

AU - Roth, A.

AU - Salazar, R.

AU - Scheithauer, W.

AU - Schmoll, H. J.

AU - Tabernero, J.

AU - Taïeb, J.

AU - Tejpar, S.

AU - Wasan, H.

AU - Yoshino, T.

AU - Zaanan, A.

AU - Arnold, D.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.

AB - Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.

KW - Clinical practice guidelines

KW - Colorectal cancer

KW - Consensus

KW - ESMO

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DO - 10.1093/annonc/mdw235

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AN - SCOPUS:84984985398

SN - 0923-7534

VL - 27

SP - 1386

EP - 1422

JO - Annals of Oncology

JF - Annals of Oncology

IS - 8

ER -

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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