ESCRT-III: An endosome-associated heterooligomeric protein complex required for MVB sorting

Markus Babst, David J. Katzmann, Eden J. Estepa-Sabal, Timo Meerloo, Scott D. Emr

Research output: Contribution to journalArticle

611 Scopus citations

Abstract

The sorting of transmembrane proteins (e.g., cell surface receptors) into the multivesicular body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT protein complexes. The soluble coiled-coil-containing proteins Vps2, Vps20, Vps24, and Snf7 are recruited from the cytoplasm to endosomal membranes where they oligomerize into a protein complex, ESCRT-III. ESCRT-III contains two functionally distinct subcomplexes. The Vps20-Snf7 subcomplex binds to the endosomal membrane, in part via the myristoyl group of Vps20. The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes.

Original languageEnglish (US)
Pages (from-to)271-282
Number of pages12
JournalDevelopmental Cell
Volume3
Issue number2
DOIs
StatePublished - Aug 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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