TY - JOUR
T1 - Erythropoietin and obstructive sleep apnea
AU - Winnicki, Mikolaj
AU - Shamsuzzaman, Abu
AU - Lanfranchi, Paola
AU - Accurso, Valentina
AU - Olson, Eric
AU - Davison, Diane
AU - Somers, Virend K.
N1 - Funding Information:
This study was supported by grants TW05399, HL-65176, HL-61560, HL-70602, HL-14388, and MOI-RR00585 from the National Institutes of Health (Bethesda, Maryland). The funding source had no involvement in the study design or in the collection, analysis, and interpretation of the data.
PY - 2004/9
Y1 - 2004/9
N2 - We tested the hypothesis that repetitive severe hypoxemia resulting from obstructive sleep apnea would increase serum erythropoietin, and that this increase would be attenuated by effective treatment of obstructive sleep apnea. We studied healthy untreated patients with obstructive sleep apnea (18 severe and 10 very mild) before and after acute treatment with continuous positive airway pressure, and 12 healthy control subjects free of obstructive sleep apnea. Baseline erythropoietin levels before sleep were similar in the obstructive sleep apnea and control groups. However, erythropoietin levels increased (by 20%, P =. 037) in patients with severe obstructive sleep apnea after 3.5 hours untreated (lowest O 2, 77% ± 3%), and decreased after 4 hours of continuous positive airway pressure treatment (P =. 001). Erythropoietin responses in patients with severe obstructive sleep apnea were different (F = 4.0, P =. 03) from controls, in whom erythropoietin levels remained stable throughout the night (P =. 94). Erythropoietin responses were similar in very mild obstructive sleep apnea and controls (P =. 58). Our results indicate that untreated severe obstructive sleep apnea results in increased erythropoietin, which decreases after continuous positive airway pressure treatment. Increased erythropoietin may be a potential reversible mechanism to explain the association between obstructive sleep apnea and cardiovascular disease.
AB - We tested the hypothesis that repetitive severe hypoxemia resulting from obstructive sleep apnea would increase serum erythropoietin, and that this increase would be attenuated by effective treatment of obstructive sleep apnea. We studied healthy untreated patients with obstructive sleep apnea (18 severe and 10 very mild) before and after acute treatment with continuous positive airway pressure, and 12 healthy control subjects free of obstructive sleep apnea. Baseline erythropoietin levels before sleep were similar in the obstructive sleep apnea and control groups. However, erythropoietin levels increased (by 20%, P =. 037) in patients with severe obstructive sleep apnea after 3.5 hours untreated (lowest O 2, 77% ± 3%), and decreased after 4 hours of continuous positive airway pressure treatment (P =. 001). Erythropoietin responses in patients with severe obstructive sleep apnea were different (F = 4.0, P =. 03) from controls, in whom erythropoietin levels remained stable throughout the night (P =. 94). Erythropoietin responses were similar in very mild obstructive sleep apnea and controls (P =. 58). Our results indicate that untreated severe obstructive sleep apnea results in increased erythropoietin, which decreases after continuous positive airway pressure treatment. Increased erythropoietin may be a potential reversible mechanism to explain the association between obstructive sleep apnea and cardiovascular disease.
KW - Erythropoietin
KW - cardiovascular disease
KW - sleep apnea syndromes
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U2 - 10.1016/j.amjhyper.2004.04.011
DO - 10.1016/j.amjhyper.2004.04.011
M3 - Article
C2 - 15363820
AN - SCOPUS:4444363044
SN - 0895-7061
VL - 17
SP - 783
EP - 786
JO - American journal of hypertension
JF - American journal of hypertension
IS - 9
ER -