TY - JOUR
T1 - Erythropoietin and cerebral vascular protection
T2 - Role of nitric oxide
AU - Santhanam, Anantha Vijay R.
AU - Katusic, Zvonimir S.
PY - 2006/11
Y1 - 2006/11
N2 - Cerebral vasospasm after subarachnoid hemorrhage (SAH) is a major clinical problem causing cerebral ischemia and infarction. The pathogenesis of vasospasm is related to a number of pathological processes including endothelial damage and alterations in vasomotor function leading to narrowing of arterial diameter and a subsequent decrease in cerebral blood flow. Discovery of the tissue protective effects of erythropoietin (EPO) stimulated the search for therapeutic application of EPO for the prevention and treatment of cerebrovascular disease. Recent studies have identified the role of EPO in vascular protection mediated by the preservation of endothelial cell integrity and stimulation of angiogenesis. In this review, we discuss the EPO-induced activation of endothelial nitric oxide (NO) synthase and its contribution to the prevention of cerebral vasospasm.
AB - Cerebral vasospasm after subarachnoid hemorrhage (SAH) is a major clinical problem causing cerebral ischemia and infarction. The pathogenesis of vasospasm is related to a number of pathological processes including endothelial damage and alterations in vasomotor function leading to narrowing of arterial diameter and a subsequent decrease in cerebral blood flow. Discovery of the tissue protective effects of erythropoietin (EPO) stimulated the search for therapeutic application of EPO for the prevention and treatment of cerebrovascular disease. Recent studies have identified the role of EPO in vascular protection mediated by the preservation of endothelial cell integrity and stimulation of angiogenesis. In this review, we discuss the EPO-induced activation of endothelial nitric oxide (NO) synthase and its contribution to the prevention of cerebral vasospasm.
KW - Cerebral vasospasm
KW - Endothelium
KW - Nitric oxide synthase
KW - Tissue protection
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U2 - 10.1111/j.1745-7254.2006.00441.x
DO - 10.1111/j.1745-7254.2006.00441.x
M3 - Review article
C2 - 17049112
AN - SCOPUS:33750282229
SN - 1671-4083
VL - 27
SP - 1389
EP - 1394
JO - Acta Pharmacologica Sinica
JF - Acta Pharmacologica Sinica
IS - 11
ER -