TY - JOUR
T1 - Erythrophagocytic Acute Lymphocytic Leukemia With B-Cell Markers and With a 20q — Chromosome Abnormality
AU - COLON-OTERO, GERARDO
AU - LI, CHIN YANG
AU - DEWALD, GORDON W.
AU - WHITE, WILLIAM L.
PY - 1984
Y1 - 1984
N2 - An erythrophagocytic neoplastic infiltration of the bone marrow which resembled malignant histiocytosis was found in an elderly man who, when initially examined, had fever and cytopenias. Results of cytochemical and immunologic studies were consistent with an acute lymphocytic leukemia in which the lymphoblasts showed the simultaneous expression of lymphoid stem cell and B-cell markers. Chromosome analysis revealed an abnormal clone with a deletion of part of the long arm of chromosome 20. This case illustrates (1) the occurrence of striking erythrophagocytosis by lymphoblasts at the time of initial presentation of a patient with acute lymphocytic leukemia, (2) the fact that abnormalities of chromosome 20 can occur in patients with acute lymphocytic leukemia, and (3) the capability of lymphoid malignant lesions to show the simultaneous expression of antigens that are characteristic of different stages of lymphoid differentiation.
AB - An erythrophagocytic neoplastic infiltration of the bone marrow which resembled malignant histiocytosis was found in an elderly man who, when initially examined, had fever and cytopenias. Results of cytochemical and immunologic studies were consistent with an acute lymphocytic leukemia in which the lymphoblasts showed the simultaneous expression of lymphoid stem cell and B-cell markers. Chromosome analysis revealed an abnormal clone with a deletion of part of the long arm of chromosome 20. This case illustrates (1) the occurrence of striking erythrophagocytosis by lymphoblasts at the time of initial presentation of a patient with acute lymphocytic leukemia, (2) the fact that abnormalities of chromosome 20 can occur in patients with acute lymphocytic leukemia, and (3) the capability of lymphoid malignant lesions to show the simultaneous expression of antigens that are characteristic of different stages of lymphoid differentiation.
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U2 - 10.1016/S0025-6196(12)62056-4
DO - 10.1016/S0025-6196(12)62056-4
M3 - Article
C2 - 6332955
AN - SCOPUS:0021232619
SN - 0025-6196
VL - 59
SP - 678
EP - 682
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 10
ER -