Erythroblastic sarcoma transformation from a chronic myeloid neoplasm with FGFR1 rearrangement presenting as a pleural effusion: a case report

Joanna C. Dalland; Alexandra Higgins; Horatiu Olteanu; Kaaren K. Reichard; Reid Meyer; Gregory E. Otteson; Patricia T. Greipp; Rebecca L. King

doi:10.1007/s12308-020-00435-3

Erythroblastic sarcoma transformation from a chronic myeloid neoplasm with FGFR1 rearrangement presenting as a pleural effusion: a case report

Joanna C. Dalland, Alexandra Higgins, Horatiu Olteanu, Kaaren K. Reichard, Reid Meyer, Gregory E. Otteson, Patricia T. Greipp, Rebecca L. King

Research output: Contribution to journal › Article › peer-review

Abstract

Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1) comprise a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, a myelodysplastic/myeloproliferative neoplasm, acute myeloid leukemia, T or B lymphoblastic leukemia/lymphoma, or mixed phenotype acute leukemia. The overall outcome of these neoplasms is poor, and these patients often show cytogenetic evolution with gain of additional chromosomal abnormalities leading to transformation to acute leukemia. Pure erythroid leukemia and erythroblastic sarcoma evolving from a preexisting chronic myeloid neoplasm have rarely been described; however, this has not been reported in MLN-FGFR1. Herein we describe a biopsy-proven chronic myeloid neoplasm with FGFR1 rearrangement with transformation to erythroblastic sarcoma presenting as a pleural effusion.

Original language	English (US)
Pages (from-to)	157-162
Number of pages	6
Journal	Journal of Hematopathology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/s12308-020-00435-3
State	Published - Jun 2021

Keywords

Erythroblastic sarcoma
FGFR1 rearrangement
Pure erythroid leukemia
Running title: Erythroblastic sarcoma transformation from chronic myeloid neoplasm with FGFR1 rearrangement

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Hematology

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10.1007/s12308-020-00435-3

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title = "Erythroblastic sarcoma transformation from a chronic myeloid neoplasm with FGFR1 rearrangement presenting as a pleural effusion: a case report",

abstract = "Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1) comprise a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, a myelodysplastic/myeloproliferative neoplasm, acute myeloid leukemia, T or B lymphoblastic leukemia/lymphoma, or mixed phenotype acute leukemia. The overall outcome of these neoplasms is poor, and these patients often show cytogenetic evolution with gain of additional chromosomal abnormalities leading to transformation to acute leukemia. Pure erythroid leukemia and erythroblastic sarcoma evolving from a preexisting chronic myeloid neoplasm have rarely been described; however, this has not been reported in MLN-FGFR1. Herein we describe a biopsy-proven chronic myeloid neoplasm with FGFR1 rearrangement with transformation to erythroblastic sarcoma presenting as a pleural effusion.",

keywords = "Erythroblastic sarcoma, FGFR1 rearrangement, Pure erythroid leukemia, Running title: Erythroblastic sarcoma transformation from chronic myeloid neoplasm with FGFR1 rearrangement",

author = "Dalland, {Joanna C.} and Alexandra Higgins and Horatiu Olteanu and Reichard, {Kaaren K.} and Reid Meyer and Otteson, {Gregory E.} and Greipp, {Patricia T.} and King, {Rebecca L.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.",

year = "2021",

month = jun,

doi = "10.1007/s12308-020-00435-3",

language = "English (US)",

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T1 - Erythroblastic sarcoma transformation from a chronic myeloid neoplasm with FGFR1 rearrangement presenting as a pleural effusion

T2 - a case report

AU - Dalland, Joanna C.

AU - Higgins, Alexandra

AU - Olteanu, Horatiu

AU - Reichard, Kaaren K.

AU - Meyer, Reid

AU - Otteson, Gregory E.

AU - Greipp, Patricia T.

AU - King, Rebecca L.

PY - 2021/6

Y1 - 2021/6

N2 - Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1) comprise a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, a myelodysplastic/myeloproliferative neoplasm, acute myeloid leukemia, T or B lymphoblastic leukemia/lymphoma, or mixed phenotype acute leukemia. The overall outcome of these neoplasms is poor, and these patients often show cytogenetic evolution with gain of additional chromosomal abnormalities leading to transformation to acute leukemia. Pure erythroid leukemia and erythroblastic sarcoma evolving from a preexisting chronic myeloid neoplasm have rarely been described; however, this has not been reported in MLN-FGFR1. Herein we describe a biopsy-proven chronic myeloid neoplasm with FGFR1 rearrangement with transformation to erythroblastic sarcoma presenting as a pleural effusion.

AB - Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1) comprise a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, a myelodysplastic/myeloproliferative neoplasm, acute myeloid leukemia, T or B lymphoblastic leukemia/lymphoma, or mixed phenotype acute leukemia. The overall outcome of these neoplasms is poor, and these patients often show cytogenetic evolution with gain of additional chromosomal abnormalities leading to transformation to acute leukemia. Pure erythroid leukemia and erythroblastic sarcoma evolving from a preexisting chronic myeloid neoplasm have rarely been described; however, this has not been reported in MLN-FGFR1. Herein we describe a biopsy-proven chronic myeloid neoplasm with FGFR1 rearrangement with transformation to erythroblastic sarcoma presenting as a pleural effusion.

KW - Erythroblastic sarcoma

KW - FGFR1 rearrangement

KW - Pure erythroid leukemia

KW - Running title: Erythroblastic sarcoma transformation from chronic myeloid neoplasm with FGFR1 rearrangement

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Erythroblastic sarcoma transformation from a chronic myeloid neoplasm with FGFR1 rearrangement presenting as a pleural effusion: a case report

Abstract

Keywords

ASJC Scopus subject areas

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