Erratum: Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice (American Journal of Physiology - Heart and Circulatory Physiology (2018) 315 (H327-H339) DOI: 10.1152/ajpheart.00688.2017)

S. Mattapally, W. Zhu, V. G. Fast, L. Gao, C. Worley, R. Kannappan, A. V. Borovjagin, J. Zhang

Abstract

Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol 315: H327-H339, 2018. First published April 6, 2018; doi:10.1152/ajpheart.00688.2017. The New & Noteworthy statement, which should appear in the Abstract, was omitted. It should read as follows (and is correct online): NEW & NOTEWORTHY Spheroids fuse in culture to produce structures with uniformly distributed cells. Furthermore, human cardiac lineage-induced pluripotent stem cells in cardiomyocytes in adjacent fused spheroids became electromechanically coupled as the fusions matured in vitro, and when the spheroids were combined with a biological matrix and administered as a patch over the infarcted region of mouse hearts, the engraftment rate exceeded 25%, and the treatment was associated with significant improvements in cardiac function via a paracrine mechanism, where exosomes released from the spheroid patch.

Original languageEnglish (US)
Pages (from-to)H731
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume315
Issue number3
DOIs
StatePublished - Sep 2018

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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