@article{c5893b7518d548ad8a3b87d8c878aad9,
title = "ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis",
abstract = "Triple-negative breast cancer (TNBC) accounts for a disproportionately high number of deaths due to a lack of targeted therapies and an increased likelihood of distant recurrence. Estrogen receptor beta (ERβ), a well-characterized tumor suppressor, is expressed in 30% of TNBCs, and its expression is associated with improved patient outcomes. We demonstrate that therapeutic activation of ERβ elicits potent anticancer effects in TNBC through the induction of a family of secreted proteins known as the cystatins, which function to inhibit canonical TGFβ signaling and suppress metastatic phenotypes both in vitro and in vivo. These data reveal the involvement of cystatins in suppressing breast cancer progression and highlight the value of ERβ-Targeted therapies for the treatment of TNBC patients.",
author = "Reese, {Jordan M.} and Bruinsma, {Elizabeth S.} and Nelson, {Adam W.} and Igor Chernukhin and Carroll, {Jason S.} and Ying Li and Malayannan Subramaniam and Suman, {Vera J.} and Vivian Negron and Monroe, {David G.} and Ingle, {James N.} and Goetz, {Matthew P.} and Hawse, {John R.}",
note = "Funding Information: ACKNOWLEDGMENTS. We thank Molly Nelson-Holte for her expertise in assisting with the animal work; Dr. Ed Leof for supplying the phospho-Smad3 antibody; Drs. Steve Johnsen and Vivek Mishra for their insight and help with the GSEA; and Dr. Rani Kalari for the statistical analysis from the Breast Cancer Genome Guided Therapy Study (BEAUTY). Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health through the Mayo Clinic Breast Cancer SPORE Grant P50CA116201 (to M.P.G. and J.R.H.); the Prospect Creek Foundation (J.R.H.); the Eisenberg Foundation (J.R.H.); the Mayo Graduate School (J.M.R.); Medical Research Council Grant MR/L00156X/1 (to A.W.N.); The Urology Foundation Scholarship Grant RESCH1302 (to A.W.N.); and NIH Grant R01AR068275 (to D.G.M.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or other funding agencies. Publisher Copyright: {\textcopyright} 2018 National Academy of Sciences.All Rights Reserved.",
year = "2018",
month = oct,
day = "9",
doi = "10.1073/pnas.1807751115",
language = "English (US)",
volume = "115",
pages = "E9580--E9589",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "41",
}