Epstein-barr-virus-related post-bone-marrow- transplant lymphoproliferative disease: Association with cytomegalovirus infection and down syndrome donor marrow

Donna F. Patton, Chris Wilkowski, Curtis A. Hanson, John H. Kersey, Bruce Bostrom, Kenneth L. McClain

Research output: Contribution to journalArticle

6 Scopus citations


We describe the development of Epstein-Barr-virus (EBV)-related lymphoproiiferative disease (LPD) in the recipient of a histocompatible bone marrow transplant (BMT). Although this rare complication is more common in recipients of mismatched bone marrow, several distinguishing features of our case may have contributed to the development of LPD in the recipient of a matched bone marrow transplant. The patient had received marrow from a sibling with Trisomy 21, a syndrome associated with variable cellular and humoral immune defects. Our patient also was infected with cytomegalovirus and was treated with immunosuppressant therapy for graft versus host disease. Although development of LPD in transplant recipients is a multifactorial process, either acquired or congenital immunosuppression/dysregulation is a common prerequisite for the process. Our case suggests that subtle immune defects in individuals with Down syndrome may contribute to the immunosuppressed setting in which EBV-related LPD can develop.

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalAmerican Journal of Pediatric Hematology/Oncology
Issue number4
StatePublished - Jan 1 1989



  • Bone marrow transplant
  • Down syndrome
  • Epstein-Barr Virus
  • Lymphoproliferative disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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