Abstract
We describe the development of Epstein-Barr-virus (EBV)-related lymphoproliferative disease (LPD) in the recipient of a histocompatible bone marrow transplant (BMT). Although this rare complication is more common in recipients of mismatched bone marrow, several distinguishing features of our case may have contributed to the development of LPD in the recipient of a matched bone marrow transplant. The patient had received marrow from a sibling with Trisomy 21, a syndrome associated with variable cellular and humoral immune defects. Our patient also was infected with cytomegalovirus and was treated with immunosuppressant therapy for graft versus host disease. Although development of LPD in transplant recipients is a multifactorial process, either acquired or congenital immunosuppression/dysregulation is a common prerequisite for the process. Our case suggests that subtle immune defects in individuals with Down syndrome may contribute to the immunosuppressed setting in which EBV-related LPD can develop.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 429-432 |
| Number of pages | 4 |
| Journal | American Journal of Pediatric Hematology/Oncology |
| Volume | 11 |
| Issue number | 4 |
| State | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hematology
- Oncology
- Pediatrics, Perinatology, and Child Health
Cite this
Epstein-Barr-virus-related post-bone-marrow-transplant lymphoproliferative disease : Association with cytomegalovirus infection and Down syndrome donor marrow. / Patton, D. F.; Wilkowski, C.; Hanson, C. A.; Kersey, J. H.; Bostrom, B.; McClain, K. L.
In: American Journal of Pediatric Hematology/Oncology, Vol. 11, No. 4, 1989, p. 429-432.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epstein-Barr-virus-related post-bone-marrow-transplant lymphoproliferative disease
T2 - Association with cytomegalovirus infection and Down syndrome donor marrow
AU - Patton, D. F.
AU - Wilkowski, C.
AU - Hanson, C. A.
AU - Kersey, J. H.
AU - Bostrom, B.
AU - McClain, K. L.
PY - 1989
Y1 - 1989
N2 - We describe the development of Epstein-Barr-virus (EBV)-related lymphoproliferative disease (LPD) in the recipient of a histocompatible bone marrow transplant (BMT). Although this rare complication is more common in recipients of mismatched bone marrow, several distinguishing features of our case may have contributed to the development of LPD in the recipient of a matched bone marrow transplant. The patient had received marrow from a sibling with Trisomy 21, a syndrome associated with variable cellular and humoral immune defects. Our patient also was infected with cytomegalovirus and was treated with immunosuppressant therapy for graft versus host disease. Although development of LPD in transplant recipients is a multifactorial process, either acquired or congenital immunosuppression/dysregulation is a common prerequisite for the process. Our case suggests that subtle immune defects in individuals with Down syndrome may contribute to the immunosuppressed setting in which EBV-related LPD can develop.
AB - We describe the development of Epstein-Barr-virus (EBV)-related lymphoproliferative disease (LPD) in the recipient of a histocompatible bone marrow transplant (BMT). Although this rare complication is more common in recipients of mismatched bone marrow, several distinguishing features of our case may have contributed to the development of LPD in the recipient of a matched bone marrow transplant. The patient had received marrow from a sibling with Trisomy 21, a syndrome associated with variable cellular and humoral immune defects. Our patient also was infected with cytomegalovirus and was treated with immunosuppressant therapy for graft versus host disease. Although development of LPD in transplant recipients is a multifactorial process, either acquired or congenital immunosuppression/dysregulation is a common prerequisite for the process. Our case suggests that subtle immune defects in individuals with Down syndrome may contribute to the immunosuppressed setting in which EBV-related LPD can develop.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024791102&partnerID=8YFLogxK
M3 - Article
C2 - 2559622
AN - SCOPUS:0024791102
VL - 11
SP - 429
EP - 432
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 4
ER -