Abstract
Objectives: The aim of this study was to characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Southern China, and to explore the relationship between EBV genotypes and NPC. Methods: The EBNA-2 gene of 32 EBV-positive NPCs and 39 EBV-positive throat washing (TW) samples from healthy individuals from Southern China was analyzed using PCR and sequencing. Results: We found E2-A to be the predominant subtype in Southern China. The distribution of EBNA-2 subtypes between NPCs and TWs was significantly different (p < 0.01) and the E2-A subtype was overly represented in NPCs. Conclusions: E2-A is the predominant subtype in Southern China, and the distribution of EBNA-2 subtypes between NPCs and TWs is significantly different. In Southern China, the E2-A subtype is significantly more frequent in NPCs than TWs, and is also more common than in Northern China. This suggests that the E2-A subtype may play an important role in the pathogenesis of NPC and that EBNA-2 gene variations are tumor-specific polymorphisms.
Original language | English (US) |
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Pages (from-to) | 386-392 |
Number of pages | 7 |
Journal | Intervirology |
Volume | 58 |
Issue number | 6 |
DOIs | |
State | Published - May 1 2016 |
Keywords
- Epstein-Barr virus
- Nasopharyngeal carcinoma
- Nuclear antigen 2
- Polymorphism
ASJC Scopus subject areas
- Virology
- Infectious Diseases