Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China

Guocai Wu, Xia Liu, Song Liu, Jun Shu, Zhifu Sun, Bing Luo

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Southern China, and to explore the relationship between EBV genotypes and NPC. Methods: The EBNA-2 gene of 32 EBV-positive NPCs and 39 EBV-positive throat washing (TW) samples from healthy individuals from Southern China was analyzed using PCR and sequencing. Results: We found E2-A to be the predominant subtype in Southern China. The distribution of EBNA-2 subtypes between NPCs and TWs was significantly different (p < 0.01) and the E2-A subtype was overly represented in NPCs. Conclusions: E2-A is the predominant subtype in Southern China, and the distribution of EBNA-2 subtypes between NPCs and TWs is significantly different. In Southern China, the E2-A subtype is significantly more frequent in NPCs than TWs, and is also more common than in Northern China. This suggests that the E2-A subtype may play an important role in the pathogenesis of NPC and that EBNA-2 gene variations are tumor-specific polymorphisms.

Original languageEnglish (US)
Pages (from-to)386-392
Number of pages7
JournalIntervirology
Volume58
Issue number6
DOIs
StatePublished - May 1 2016

Keywords

  • Epstein-Barr virus
  • Nasopharyngeal carcinoma
  • Nuclear antigen 2
  • Polymorphism

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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