Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China

Guocai Wu, Xia Liu, Song Liu, Jun Shu, Zhifu D Sun, Bing Luo

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Southern China, and to explore the relationship between EBV genotypes and NPC. Methods: The EBNA-2 gene of 32 EBV-positive NPCs and 39 EBV-positive throat washing (TW) samples from healthy individuals from Southern China was analyzed using PCR and sequencing. Results: We found E2-A to be the predominant subtype in Southern China. The distribution of EBNA-2 subtypes between NPCs and TWs was significantly different (p <0.01) and the E2-A subtype was overly represented in NPCs. Conclusions: E2-A is the predominant subtype in Southern China, and the distribution of EBNA-2 subtypes between NPCs and TWs is significantly different. In Southern China, the E2-A subtype is significantly more frequent in NPCs than TWs, and is also more common than in Northern China. This suggests that the E2-A subtype may play an important role in the pathogenesis of NPC and that EBNA-2 gene variations are tumor-specific polymorphisms.

Original languageEnglish (US)
Pages (from-to)386-392
Number of pages7
JournalIntervirology
Volume58
Issue number6
DOIs
StatePublished - May 1 2016

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Human Herpesvirus 4
China
Pharynx
Genes
Nasopharyngeal carcinoma
Genotype
Tissue Donors
Polymerase Chain Reaction
Neoplasms

Keywords

  • Epstein-Barr virus
  • Nasopharyngeal carcinoma
  • Nuclear antigen 2
  • Polymorphism

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China. / Wu, Guocai; Liu, Xia; Liu, Song; Shu, Jun; Sun, Zhifu D; Luo, Bing.

In: Intervirology, Vol. 58, No. 6, 01.05.2016, p. 386-392.

Research output: Contribution to journalArticle

Wu, Guocai ; Liu, Xia ; Liu, Song ; Shu, Jun ; Sun, Zhifu D ; Luo, Bing. / Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China. In: Intervirology. 2016 ; Vol. 58, No. 6. pp. 386-392.
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