Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder following lung transplantation is more commonly of host origin

Michael R. Peterson, Shawn C. Emery, Gordon L. Yung, Eliezer Masliah, Eunhee S. Yi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Context. - Posttransplantation lymphoproliferative disorder (PTLD) in patients who have undergone solid organ transplantation is thought to be mostly of host (ie, transplant recipient) origin, as opposed to being predominantly of donor origin, which is observed in patients who have undergone bone marrow transplantation. Donor-origin PTLDs reportedly follow a more indolent course than host-origin PTLDs. Objective. - To determine the origin of PTLD and its clinical implications in patients who have undergone lung transplantation. Design. - Patients' medical records were reviewed for clinical data. We performed a molecular study to determine the origin of abnormal lymphoid cells in 4 PTLD cases identified from our autopsy files. Each case underwent restriction fragment length polymorphism analysis using polymerase chain reaction-based genotyping for CYP2D6. Epstein-Barr virus (latent membrane protein 1) immunostaining and polymerase chain reaction analysis were performed on PTLD-involved tissues. Results. - Three of 4 PTLD cases were of host origin, and the remaining case was of donor origin. Epstein-Barr virus was detected by immunohistochemical and polymerase chain reaction methods in all PTLD-involved tissues that were examined. There was no apparent difference in clinical manifestations between host-origin and donor-origin PTLD cases in our study. Conclusions. - The PTLDs in our patients who had undergone lung transplantation were Epstein-Barr virus-positive and mostly of host origin, without any notable clinical difference from donor-origin PTLD.

Original languageEnglish (US)
Pages (from-to)176-180
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number2
StatePublished - Feb 2006
Externally publishedYes

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Lymphoproliferative Disorders
Lung Transplantation
Human Herpesvirus 4
Tissue Donors
Polymerase Chain Reaction
Cytochrome P-450 CYP2D6
Organ Transplantation
Bone Marrow Transplantation
Restriction Fragment Length Polymorphisms
Medical Records
Autopsy
Lymphocytes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder following lung transplantation is more commonly of host origin. / Peterson, Michael R.; Emery, Shawn C.; Yung, Gordon L.; Masliah, Eliezer; Yi, Eunhee S.

In: Archives of Pathology and Laboratory Medicine, Vol. 130, No. 2, 02.2006, p. 176-180.

Research output: Contribution to journalArticle

Peterson, Michael R. ; Emery, Shawn C. ; Yung, Gordon L. ; Masliah, Eliezer ; Yi, Eunhee S. / Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder following lung transplantation is more commonly of host origin. In: Archives of Pathology and Laboratory Medicine. 2006 ; Vol. 130, No. 2. pp. 176-180.
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