EPO tecting the endothelium

T. E. Peterson, Z. S. Katusic

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Erythropoietin is a 30.4 kDa protein that is produced and secreted from the kidney in response to anemia and hypobaric hypoxia. Binding of EPO to its receptor (EPO-R) on bone marrow-derived erythroid progenitor cells results in the stimulation of red blood cell production. Evidence is accumulating however, that the biological effects of recombinant EPO therapy extend beyond the stimulation of erythropoiesis. The discovery that the EPO-R is expressed on vascular endothelial cells suggests that the vasculature may be a biological target of EPO. Indeed, several studies have now demonstrated that the protective effect of EPO administration involves the activation of the protein kinase B/Akt pathway which can protect cells from apoptosis. Future work is likely to provide further insight into the mechanisms by which EPO protects vascular endothelial cells from injury and give us a better understanding of the pharmacological doses that are required to achieve this protection.

Original languageEnglish (US)
Pages (from-to)823-825
Number of pages3
JournalBritish Journal of Pharmacology
Volume150
Issue number7
DOIs
StatePublished - Apr 1 2007

ASJC Scopus subject areas

  • Pharmacology

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