Epitope-specific anti-neutrophil cytoplasmic antibodies: Do they matter? Can they be detected?

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Proteinase 3 (PR3)-anti-neutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase (MPO)-ANCA are suggested to play a pathogenic role as they are closely related to the small-vessel vasculitis syndromes, Wegener's granulomatosis and microscopic polyangiitis. A large body of in vitro and animal experiments supports this concept. The mechanisms of action involve a direct interaction between ANCA and its antigen. The epitope specificity of ANCA may therefore influence the functional effects of ANCA and/or may reflect the mechanisms behind different disease manifestations or disease courses.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalAPMIS
Volume117
Issue numberSUPPL. 127
DOIs
StatePublished - Jun 2009

Keywords

  • ANCA
  • Chimeric molecules
  • Conformational epitopes
  • Epitope specificity
  • Monoclonal antibodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

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