Abstract
Proteinase 3 (PR3)-anti-neutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase (MPO)-ANCA are suggested to play a pathogenic role as they are closely related to the small-vessel vasculitis syndromes, Wegener's granulomatosis and microscopic polyangiitis. A large body of in vitro and animal experiments supports this concept. The mechanisms of action involve a direct interaction between ANCA and its antigen. The epitope specificity of ANCA may therefore influence the functional effects of ANCA and/or may reflect the mechanisms behind different disease manifestations or disease courses.
Original language | English (US) |
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Pages (from-to) | 63-66 |
Number of pages | 4 |
Journal | APMIS |
Volume | 117 |
Issue number | SUPPL. 127 |
DOIs | |
State | Published - Jun 2009 |
Keywords
- ANCA
- Chimeric molecules
- Conformational epitopes
- Epitope specificity
- Monoclonal antibodies
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Immunology and Allergy
- Microbiology (medical)