Epithelial mucin genes

Sandra J. Gendler, Andrew P. Spicer

Research output: Contribution to journalReview article

812 Scopus citations

Abstract

The last seven years have been exciting in the world of mucin biology. Molecular analyses of mucin genes and deduced protein structures have provided insight into structural features of mucins and tools with which to examine expression, secretion, and glycosylation, thereby enabling a better understanding of the role of mucins in normal physiological processes and in disease. Functional studies are in progress both in vitro using cDNAs and cell lines and in vivo utilizing mutant mice in which a particular mucin gene has been inactivated or overexpressed. These studies should help determine whether the functions of mucins are restricted to protection and lubrication, or if they are involved in the adhesion of tumor cells to other cells or tissue components or in modulation of the immune system.

Original languageEnglish (US)
Pages (from-to)607-634
Number of pages28
JournalAnnual Review of Physiology
Volume57
DOIs
StatePublished - Jan 1 1995

Keywords

  • MUC
  • O-glycosylation
  • glycoprotein
  • mucus
  • tandem repeat

ASJC Scopus subject areas

  • Physiology

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