TY - JOUR
T1 - Epithelial-mesenchymal transition
T2 - General principles and pathological relevance with special emphasis on the role of matrix metalloproteinases
AU - Nisticò, Paola
AU - Bissell, Mina J.
AU - Radisky, Derek C.
PY - 2012/2
Y1 - 2012/2
N2 - Epithelial-mesenchymal transition (EMT) is a physiological process in which epithelial cells acquire the motile and invasive characteristics of mesenchymal cells. Although EMTin embryonic development is a coordinated, organized process involving interaction between many different cells and tissue types, aspects of the EMT program can be inappropriately activated in response to microenvironmental alterations and aberrant stimuli, and this can contribute to disease conditions including tissue fibrosis and cancer progression. Here we will outline how EMT functions in normal development, how it could be activated in pathologic conditions- especially by matrix metalloproteinases-and how it may be targeted for therapeutic benefit.
AB - Epithelial-mesenchymal transition (EMT) is a physiological process in which epithelial cells acquire the motile and invasive characteristics of mesenchymal cells. Although EMTin embryonic development is a coordinated, organized process involving interaction between many different cells and tissue types, aspects of the EMT program can be inappropriately activated in response to microenvironmental alterations and aberrant stimuli, and this can contribute to disease conditions including tissue fibrosis and cancer progression. Here we will outline how EMT functions in normal development, how it could be activated in pathologic conditions- especially by matrix metalloproteinases-and how it may be targeted for therapeutic benefit.
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U2 - 10.1101/cshperspect.a011908
DO - 10.1101/cshperspect.a011908
M3 - Article
C2 - 22300978
AN - SCOPUS:84860830113
SN - 1943-0264
VL - 4
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 2
ER -