Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

Georgia Chenevix-Trench on behalf of the AOCS management group

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P <0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value

Original languageEnglish (US)
Pages (from-to)689-697
Number of pages9
JournalGenetic Epidemiology
Volume39
Issue number8
DOIs
StatePublished - Dec 1 2015

Fingerprint

Epithelial-Mesenchymal Transition
Genes
Single Nucleotide Polymorphism
Neoplasms
Genome-Wide Association Study
Sample Size
Epithelial Cells
Neoplasm Metastasis
Carcinoma
Ovarian epithelial cancer
Population

Keywords

  • Epithelial-mesenchymal transition
  • Ovarian cancer
  • Single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk. / Georgia Chenevix-Trench on behalf of the AOCS management group.

In: Genetic Epidemiology, Vol. 39, No. 8, 01.12.2015, p. 689-697.

Research output: Contribution to journalArticle

Georgia Chenevix-Trench on behalf of the AOCS management group 2015, 'Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk', Genetic Epidemiology, vol. 39, no. 8, pp. 689-697. https://doi.org/10.1002/gepi.21921
Georgia Chenevix-Trench on behalf of the AOCS management group. / Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk. In: Genetic Epidemiology. 2015 ; Vol. 39, No. 8. pp. 689-697.
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