Epithelial-fibroblast interactions in response to mechanical stresses in the airways: an in vitro study

Melody Swartz; Daniel Tschumperlin; Barbara Ressler; Roger Kamm; Jeffrey Drazen

Epithelial-fibroblast interactions in response to mechanical stresses in the airways: an in vitro study

Melody Swartz, Daniel Tschumperlin, Barbara Ressler, Roger Kamm, Jeffrey Drazen

Physiology & Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A study was carried out to investigate the effects of mechanical forces on matrix production in the airways using novel in vitro techniques. Focus was on the communication between airway epithelial cells, which are subject to normal stresses, and fibroblasts, which are primarily responsible for the remodeling of the extracellular matrix. The epithelial cells were subjected to static or dynamic air pressure differentials of 0-20 cm water for 8 hours while the fibroblasts remained unstressed. Response was measured in terms of direct production and degradation of matrix molecules by both cell types as well as changes in expression of signaling molecules.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	431-432
Number of pages	2
Volume	42
ISBN (Print)	0791816117
State	Published - 1999
Event	1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999

Other

Other	1999 Bioengineering Conference
City	Big Sky, MT, USA
Period	6/16/99 → 6/20/99

ASJC Scopus subject areas

General Engineering

Cite this

Epithelial-fibroblast interactions in response to mechanical stresses in the airways: an in vitro study. / Swartz, Melody; Tschumperlin, Daniel; Ressler, Barbara et al.
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 42 ASME, 1999. p. 431-432.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Kamm, Roger

AU - Drazen, Jeffrey

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AB - A study was carried out to investigate the effects of mechanical forces on matrix production in the airways using novel in vitro techniques. Focus was on the communication between airway epithelial cells, which are subject to normal stresses, and fibroblasts, which are primarily responsible for the remodeling of the extracellular matrix. The epithelial cells were subjected to static or dynamic air pressure differentials of 0-20 cm water for 8 hours while the fibroblasts remained unstressed. Response was measured in terms of direct production and degradation of matrix molecules by both cell types as well as changes in expression of signaling molecules.

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BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

Y2 - 16 June 1999 through 20 June 1999

ER -

Epithelial-fibroblast interactions in response to mechanical stresses in the airways: an in vitro study

Abstract

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ASJC Scopus subject areas

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