Epithelial cancer detection by oblique-incidence optical spectroscopy

Alejandro Garcia-Uribe, Karthik C. Balareddy, Jun Zou, Kenneth K. Wang, Madeleine Duvic, Lihong V. Wang

Research output: Contribution to journalConference article

2 Scopus citations

Abstract

This paper presents a study on non-invasive detection of two common epithelial cancers (skin and esophagus) based on oblique incidence diffuse reflectance spectroscopy (OIDRS). An OIDRS measurement system, which combines fiber optics and MEMS technologies, was developed. In our pilot studies, a total number of 137 cases have been measured in-vivo for skin cancer detection and a total number of 20 biopsy samples have been measured ex-vivo for esophageal cancer detection. To automatically differentiate the cancerous cases from benign ones, a statistical software classification program was also developed. An overall classification accuracy of 90% and 100% has been achieved for skin and esophageal cancer classification, respectively.

Original languageEnglish (US)
Article number71690A
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7169
DOIs
StatePublished - Jun 8 2009
EventAdvanced Biomedical and Clinical Diagnostic Systems VII - San Jose, CA, United States
Duration: Jan 25 2009Jan 26 2009

Keywords

  • Cancer detection
  • MEMS
  • Oblique incidence
  • Spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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