Epilepsy in children-when should we think neurometabolic disease?

Radhika Dhamija, Marc C. Patterson, Elaine C. Wirrell

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Seizures are often the first manifestation of central nervous system dysfunction and are common in many inborn errors of metabolism, especially in neonates, infants, and children. A high index of suspicion is required to diagnose inborn errors of metabolism as the cause of seizures. It is also important to recognize these metabolic disorders early, as specific disease-modifying treatments are available for some with favorable long-term outcomes. This review discusses the classification of metabolic disorders as a cause of seizures based on pathogenesis and age and proposes a tiered approach for cost-effective diagnosis of metabolic disorders.

Original languageEnglish (US)
Pages (from-to)663-671
Number of pages9
JournalJournal of child neurology
Volume27
Issue number5
DOIs
StatePublished - May 1 2012

Keywords

  • epilepsy
  • pathogenesis metabolism
  • seizures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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