Epilepsy in children-when should we think neurometabolic disease?

Radhika Dhamija, Marc C. Patterson, Elaine C Wirrell

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Seizures are often the first manifestation of central nervous system dysfunction and are common in many inborn errors of metabolism, especially in neonates, infants, and children. A high index of suspicion is required to diagnose inborn errors of metabolism as the cause of seizures. It is also important to recognize these metabolic disorders early, as specific disease-modifying treatments are available for some with favorable long-term outcomes. This review discusses the classification of metabolic disorders as a cause of seizures based on pathogenesis and age and proposes a tiered approach for cost-effective diagnosis of metabolic disorders.

Original languageEnglish (US)
Pages (from-to)663-671
Number of pages9
JournalJournal of Child Neurology
Volume27
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Inborn Errors Metabolism
Epilepsy
Seizures
Central Nervous System
Newborn Infant
Costs and Cost Analysis
Therapeutics

Keywords

  • epilepsy
  • pathogenesis metabolism
  • seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Epilepsy in children-when should we think neurometabolic disease? / Dhamija, Radhika; Patterson, Marc C.; Wirrell, Elaine C.

In: Journal of Child Neurology, Vol. 27, No. 5, 05.2012, p. 663-671.

Research output: Contribution to journalArticle

Dhamija, Radhika ; Patterson, Marc C. ; Wirrell, Elaine C. / Epilepsy in children-when should we think neurometabolic disease?. In: Journal of Child Neurology. 2012 ; Vol. 27, No. 5. pp. 663-671.
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