Epigenetics of gastrointestinal diseases: notes from a workshop

David L. Marks, Rachel L. Olson, Raul Alfredo Urrutia, Daniel D. Billadeau, Nilotpal Roy, George A. Calin, Muller Fabbri, Marina Koutsioumpa, Dimitrios Iliopoulos, Tamas Ordog, Robert Huebert, Olga Sarmento, Adebowale O. Bamidele, William Faubion, Gwen L. Lomberk, Jens Siveke, Nita Ahuja, Juan Iovanna, Ryan A. Hlady, Keith RobertsonJohn Kisiel, Christopher L. Pin, Martin E. Fernandez-Zapico

Research output: Contribution to journalArticle

Abstract

International experts gathered at the Mayo Clinic (Rochester MN, USA) on February 27th-28th, 2017 for a meeting entitled ‘Basic and Translational Facets of the Epigenetics of GI Diseases’. This workshop summarized recent advances on the role of epigenetics in the pathobiology of gastrointestinal (GI) diseases. Highlights of the meeting included recent advances on the involvement of different epigenetic mechanisms in malignant and nonmalignant GI disorders and the epigenetic heterogeneity exhibited in these diseases. The translational value of epigenetic drugs, as well as the current and future use of epigenetic changes (i.e., DNA methylation patterns) as biomarkers for early detection tools or disease stratification were also important topics of discussion.

Original languageEnglish (US)
Pages (from-to)449-457
Number of pages9
JournalEpigenetics
Volume13
Issue number4
DOIs
StatePublished - Apr 3 2018

Keywords

  • biomarkers
  • chromatin
  • DNA methylation
  • epigenetics
  • Gastrointestinal diseases
  • miRNA
  • therapeutics

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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  • Cite this

    Marks, D. L., Olson, R. L., Urrutia, R. A., Billadeau, D. D., Roy, N., Calin, G. A., Fabbri, M., Koutsioumpa, M., Iliopoulos, D., Ordog, T., Huebert, R., Sarmento, O., Bamidele, A. O., Faubion, W., Lomberk, G. L., Siveke, J., Ahuja, N., Iovanna, J., Hlady, R. A., ... Fernandez-Zapico, M. E. (2018). Epigenetics of gastrointestinal diseases: notes from a workshop. Epigenetics, 13(4), 449-457. https://doi.org/10.1080/15592294.2018.1464351