Epigenetics of cancer-associated muscle catabolism

Ryan M. Carr, Elisa Enriquez-Hesles, Rachel L.O. Olson, Aminah Jatoi, Jason Doles, Martin E. Fernandez-Zapico

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy. Nutritional support has been ineffective in treating this process leading to investigations into the underlying molecular processes governing muscle catabolism. In this commentary, we discuss the molecular mechanisms of cancer-associated muscle metabolism and the epigenetic processes responsible for the muscle wasting phenotype. Ultimately, we highlight how the epigenome may serve as a promising therapeutic target in reversing cancer-associated muscle catabolism.

Original languageEnglish (US)
Pages (from-to)1259-1265
Number of pages7
JournalEpigenomics
Volume9
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • cachexia
  • cancer
  • epigenetics
  • muscle wasting
  • weight loss

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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