Avoiding the inhibitory effects of p53 on cell growth is important for tumor progression. In this issue of Cancer Cell, Picchiorri et al. describe epigenetic silencing of MDM2-targeting microRNAs in multiple myeloma (MM), which generally appears to have intact p53 function. This provides the rationale for microRNA-targeted therapy for MM.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Oct 19 2010|
ASJC Scopus subject areas
- Cell Biology
- Cancer Research