Epigenetics and MicroRNAs combine to modulate the MDM2/p53 axis in myeloma

Research output: Contribution to journalShort survey

10 Scopus citations

Abstract

Avoiding the inhibitory effects of p53 on cell growth is important for tumor progression. In this issue of Cancer Cell, Picchiorri et al. describe epigenetic silencing of MDM2-targeting microRNAs in multiple myeloma (MM), which generally appears to have intact p53 function. This provides the rationale for microRNA-targeted therapy for MM.

Original languageEnglish (US)
Pages (from-to)299-300
Number of pages2
JournalCancer cell
Volume18
Issue number4
DOIs
StatePublished - Oct 19 2010

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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