Epigenetics and MicroRNAs combine to modulate the MDM2/p53 axis in myeloma

Marta Chesi; P. Leif Bergsagel

doi:10.1016/j.ccr.2010.10.004

Epigenetics and MicroRNAs combine to modulate the MDM2/p53 axis in myeloma

Marta Chesi, P. Leif Bergsagel

Hematology/Oncology

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Avoiding the inhibitory effects of p53 on cell growth is important for tumor progression. In this issue of Cancer Cell, Picchiorri et al. describe epigenetic silencing of MDM2-targeting microRNAs in multiple myeloma (MM), which generally appears to have intact p53 function. This provides the rationale for microRNA-targeted therapy for MM.

Original language	English (US)
Pages (from-to)	299-300
Number of pages	2
Journal	Cancer cell
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.ccr.2010.10.004
State	Published - Oct 19 2010

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2010.10.004

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title = "Epigenetics and MicroRNAs combine to modulate the MDM2/p53 axis in myeloma",

abstract = "Avoiding the inhibitory effects of p53 on cell growth is important for tumor progression. In this issue of Cancer Cell, Picchiorri et al. describe epigenetic silencing of MDM2-targeting microRNAs in multiple myeloma (MM), which generally appears to have intact p53 function. This provides the rationale for microRNA-targeted therapy for MM.",

author = "Marta Chesi and Bergsagel, {P. Leif}",

year = "2010",

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AU - Bergsagel, P. Leif

PY - 2010/10/19

Y1 - 2010/10/19

N2 - Avoiding the inhibitory effects of p53 on cell growth is important for tumor progression. In this issue of Cancer Cell, Picchiorri et al. describe epigenetic silencing of MDM2-targeting microRNAs in multiple myeloma (MM), which generally appears to have intact p53 function. This provides the rationale for microRNA-targeted therapy for MM.

AB - Avoiding the inhibitory effects of p53 on cell growth is important for tumor progression. In this issue of Cancer Cell, Picchiorri et al. describe epigenetic silencing of MDM2-targeting microRNAs in multiple myeloma (MM), which generally appears to have intact p53 function. This provides the rationale for microRNA-targeted therapy for MM.

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DO - 10.1016/j.ccr.2010.10.004

M3 - Short survey

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EP - 300

JO - Cancer cell

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Epigenetics and MicroRNAs combine to modulate the MDM2/p53 axis in myeloma

Abstract

ASJC Scopus subject areas

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