Epigenetics and autosomal dominant polycystic kidney disease

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

The roles of epigenetic modulation of gene expression and protein functions in autosomal dominant polycystic kidney disease (ADPKD) have recently become the focus of scientific investigation. Evidence generated to date indicates that one of the epigenetic modifiers, histone deacetylases (HDACs), are important regulators of ADPKD. HDACs are involved in regulating the expression of the Pkd1 gene and are the target of fluid flow-induced calcium signal in kidney epithelial cells. Pharmacological inhibition of HDAC activity has been found to reduce the progression of cyst formation and slow the decline of kidney function in Pkd1 conditional knockout mice and Pkd2 knockout mice, respectively, implicating the potential clinical application of HDAC inhibitors on ADPKD. Since the expression of HDAC6 is upregulated in cystic epithelial cells, the potential roles of HDAC6 in regulating cilia resorption and epidermal growth factor receptor (EGFR) trafficking through deacetylating α-tubulin and regulating Wnt signaling through deacetylating β-catenin are also discussed.

Original languageEnglish (US)
Pages (from-to)1213-1218
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1812
Issue number10
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Fingerprint

Autosomal Dominant Polycystic Kidney
Histone Deacetylases
Epigenomics
Knockout Mice
Epithelial Cells
Kidney
Gene Expression
Catenins
Cilia
Tubulin
Epidermal Growth Factor Receptor
Cysts
Pharmacology
Calcium
Proteins

Keywords

  • α-Tubulin
  • Autosomal dominant polycystic kidney disease
  • Epidermal growth factor receptor
  • Epigenetic
  • HDAC inhibitor
  • Histone deacetylases

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Epigenetics and autosomal dominant polycystic kidney disease. / Li, Xiaogang.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1812, No. 10, 01.10.2011, p. 1213-1218.

Research output: Contribution to journalReview article

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