Epigenetics: A promising paradigm for better understanding and managing pain

Seungmae Seo, Adrienne Grzenda, Gwen Lomberk, Xiao Ming Ou, Ricardo A. Cruciani, Raul Urrutia

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Epigenetic regulation of gene expression is a rapidly growing area of research. Considering the longevity and plasticity of neurons, the studies on epigenetic pathways in the nervous system should be of special interest for both epigeneticists and neuroscientists. Activation or inactivation of different epigenetic pathways becomes more pronounced when the cells experience rapid changes in their environment, and such changes can be easily caused by injury and inflammation, resulting in pain perception or distortion of pain perception (eg, hyperalgesia). Therefore, in this regard, the field of pain is at an advantage to study the epigenetic pathways. More importantly, understanding pain from an epigenetics point of view would provide a new paradigm for developing drugs or strategies for pain management. In this review, we introduce basic concepts of epigenetics, including chromatin dynamics, histone modifications, DNA methylation, and RNA-induced gene silencing. In addition, we provide evidence from published studies suggesting wide implication of different epigenetic pathways within pain pathways. Perspective: This article provides a brief overview of epigenetic pathways for gene regulation and highlights their involvement in pain. Our goal is to expose the readers to these concepts so that pain-related phenotypes can be investigated from the epigenetic point of view.

Original languageEnglish (US)
Pages (from-to)549-557
Number of pages9
JournalJournal of Pain
Volume14
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Epigenomics
Pain
Pain Perception
Histone Code
Hyperalgesia
Gene Expression Regulation
Gene Silencing
DNA Methylation
Pain Management
Nervous System
Chromatin
RNA
Inflammation
Phenotype
Neurons
Wounds and Injuries
Research
Pharmaceutical Preparations
Genes

Keywords

  • chromatin
  • DNA methylation
  • epigenetic
  • histone modification
  • opioid receptors
  • Pain
  • transcription factor

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neurology
  • Clinical Neurology

Cite this

Seo, S., Grzenda, A., Lomberk, G., Ou, X. M., Cruciani, R. A., & Urrutia, R. (2013). Epigenetics: A promising paradigm for better understanding and managing pain. Journal of Pain, 14(6), 549-557. https://doi.org/10.1016/j.jpain.2013.01.772

Epigenetics : A promising paradigm for better understanding and managing pain. / Seo, Seungmae; Grzenda, Adrienne; Lomberk, Gwen; Ou, Xiao Ming; Cruciani, Ricardo A.; Urrutia, Raul.

In: Journal of Pain, Vol. 14, No. 6, 06.2013, p. 549-557.

Research output: Contribution to journalArticle

Seo, S, Grzenda, A, Lomberk, G, Ou, XM, Cruciani, RA & Urrutia, R 2013, 'Epigenetics: A promising paradigm for better understanding and managing pain', Journal of Pain, vol. 14, no. 6, pp. 549-557. https://doi.org/10.1016/j.jpain.2013.01.772
Seo, Seungmae ; Grzenda, Adrienne ; Lomberk, Gwen ; Ou, Xiao Ming ; Cruciani, Ricardo A. ; Urrutia, Raul. / Epigenetics : A promising paradigm for better understanding and managing pain. In: Journal of Pain. 2013 ; Vol. 14, No. 6. pp. 549-557.
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