Epigenetic silencing of tumor suppressor genes in pancreatic cancer

Gwen A. Lomberk

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Introduction: Without any alteration of DNA sequence, heritable changes in gene expression, caused by epigenetic pathways, are gaining a spotlight in research of diseases, and in particular, cancer. Although the dominant paradigm in cancer research, proposed by Vogelstein, suggested that cancer progression was caused by a sequential accumulation of genetic aberrations, basic science studies in epigenetics have now advanced our knowledge enough to apply its concepts and methodology to the study of cancer. In fact, chromatin dynamics and small RNAs are altered far more prevalently in cancer than genetic alterations and most important, can be reversible, lending themselves as attractive therapeutic targets. Concluding Remarks: In the current review, the inactivation of p16 will be utilized as the most prominent example of epigenetic silencing of a tumor suppressor gene in pancreatic cancer. In addition, fundamental insight will be given into why and how epigenetics can be targeted for therapeutic purposes. This knowledge will help the reader in determining the breadth and depth of this field of study with potentially high impact to oncology.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalJournal of Gastrointestinal Cancer
Volume42
Issue number2
DOIs
StatePublished - Jun 2011

Fingerprint

Tumor Suppressor Genes
Pancreatic Neoplasms
Epigenomics
Neoplasms
Research
Chromatin
RNA
Gene Expression
Therapeutics

Keywords

  • Chromatin
  • Epigenetic silencing
  • Histones
  • Pancreatic cancer
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Gastroenterology
  • Oncology

Cite this

Epigenetic silencing of tumor suppressor genes in pancreatic cancer. / Lomberk, Gwen A.

In: Journal of Gastrointestinal Cancer, Vol. 42, No. 2, 06.2011, p. 93-99.

Research output: Contribution to journalArticle

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