Epigenetic mechanisms and genome stability

Emily L. Putiri, Keith D Robertson

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Epigenetic marks are well recognized as heritable chemical modifications of DNA and chromatin that induce chromatin structural changes thereby affecting gene activity. A lesser-known phenomenon is the pervasive effects these marks have on genomic integrity. Remarkably, epigenetic marks and the enzymes that establish them are involved in multiple aspects of maintaining genetic content. These aspects include preserving nucleotide sequences such as repetitive elements, preventing DNA damage, functioning in DNA repair mechanisms and chromatin restoration, and defining chromosomal organization through effects on structural elements such as the centromere. This review discusses these functional aspects of epigenetic marks and their effects on human health and disease.

Original languageEnglish (US)
Pages (from-to)299-314
Number of pages16
JournalClinical Epigenetics
Volume2
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Genomic Instability
Epigenomics
Chromatin
Centromere
DNA Repair
DNA Damage
DNA
Health
Enzymes
Genes

Keywords

  • Centromere
  • DNA methylation
  • DNA repair
  • Histone modifications
  • Microsatellite instability (MSI)

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Developmental Biology
  • Genetics(clinical)

Cite this

Epigenetic mechanisms and genome stability. / Putiri, Emily L.; Robertson, Keith D.

In: Clinical Epigenetics, Vol. 2, No. 2, 08.2011, p. 299-314.

Research output: Contribution to journalArticle

Putiri, Emily L. ; Robertson, Keith D. / Epigenetic mechanisms and genome stability. In: Clinical Epigenetics. 2011 ; Vol. 2, No. 2. pp. 299-314.
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