Epigenetic changes in gliomas

Rebecca Burgess, Robert Jenkins, Zhiguo Zhang

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Epigenetics are defined, in broad-terms, as alterations in gene expression without changes in DNA sequence. While histone modifications and DNA methylation are two classical means to regulate gene expression, miRNA has also recently been documented to govern gene expression in normal as well as cancer cells. In this review, we will first describe briefly histone modifications, DNA methylation and miRNAs and the functions of these epigenetic marks during different cellular processes involving DNA metabolism. We will then highlight some epigenetic changes in glioblastomas, a malignant form of brain tumor, and potential application of epigenetic means for diagnosis, prognosis, and treatment of gliomas. We expect that novel therapies will be developed to counter epigenetic changes in this deadly disease.

Original languageEnglish (US)
Pages (from-to)1326-1334
Number of pages9
JournalCancer Biology and Therapy
Volume7
Issue number9
DOIs
StatePublished - Sep 2008

    Fingerprint

Keywords

  • Cell cycle
  • Nuclear PTEN and glioblastoma
  • P53
  • PI3K
  • PTEN

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Cite this