Epigenetic changes in gliomas

Rebecca Burgess, Robert Brian Jenkins, Zhiguo Zhang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Epigenetics are defined, in broad-terms, as alterations in gene expression without changes in DNA sequence. While histone modifications and DNA methylation are two classical means to regulate gene expression, miRNA has also recently been documented to govern gene expression in normal as well as cancer cells. In this review, we will first describe briefly histone modifications, DNA methylation and miRNAs and the functions of these epigenetic marks during different cellular processes involving DNA metabolism. We will then highlight some epigenetic changes in glioblastomas, a malignant form of brain tumor, and potential application of epigenetic means for diagnosis, prognosis, and treatment of gliomas. We expect that novel therapies will be developed to counter epigenetic changes in this deadly disease.

Original languageEnglish (US)
Pages (from-to)1326-1334
Number of pages9
JournalCancer Biology and Therapy
Volume7
Issue number9
StatePublished - Sep 2008

Fingerprint

Epigenomics
Glioma
Histone Code
DNA Methylation
MicroRNAs
Gene Expression
Glioblastoma
Brain Neoplasms
DNA
Neoplasms
Therapeutics

Keywords

  • Cell cycle
  • Nuclear PTEN and glioblastoma
  • P53
  • PI3K
  • PTEN

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine
  • Pharmacology

Cite this

Burgess, R., Jenkins, R. B., & Zhang, Z. (2008). Epigenetic changes in gliomas. Cancer Biology and Therapy, 7(9), 1326-1334.

Epigenetic changes in gliomas. / Burgess, Rebecca; Jenkins, Robert Brian; Zhang, Zhiguo.

In: Cancer Biology and Therapy, Vol. 7, No. 9, 09.2008, p. 1326-1334.

Research output: Contribution to journalArticle

Burgess, R, Jenkins, RB & Zhang, Z 2008, 'Epigenetic changes in gliomas', Cancer Biology and Therapy, vol. 7, no. 9, pp. 1326-1334.
Burgess R, Jenkins RB, Zhang Z. Epigenetic changes in gliomas. Cancer Biology and Therapy. 2008 Sep;7(9):1326-1334.
Burgess, Rebecca ; Jenkins, Robert Brian ; Zhang, Zhiguo. / Epigenetic changes in gliomas. In: Cancer Biology and Therapy. 2008 ; Vol. 7, No. 9. pp. 1326-1334.
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