Epigenetic alterations in gastric carcinogenesis

In Seon Choi, Tsung Teh Wu

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

Gastric cancer is believed to result in part from the accumulation of multiple genetic alterations leading to oncogene overexpression and tumor suppressor loss. Epigenetic alterations as a distinct and crucial mechanism to silence a variety of methylated tissue-specific and imprinted genes, have been extensively studied in gastric carcinoma and play important roles in gastric carcinogenesis. This review will briefly discuss the basic aspects of DNA methylation and CpG island methylation, in particular the epigenetic alterations of certain critical genes implicated in gastric carcinogenesis and its relevance of clinical implications.

Original languageEnglish (US)
Pages (from-to)247-254
Number of pages8
JournalCell Research
Volume15
Issue number4
DOIs
StatePublished - Nov 25 2005

Keywords

  • Adenocarcinoma
  • Chronic gastritis
  • Dysplasia/adenoma
  • Epigenetic alterations
  • Gastric carcinogenesis
  • Intestinal metaplasia

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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