Epigenetic alterations in gastric carcinogenesis

In Seon Choi; Tsung Teh Wu

doi:10.1038/sj.cr.7290293

Epigenetic alterations in gastric carcinogenesis

In Seon Choi, Tsung Teh Wu

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Gastric cancer is believed to result in part from the accumulation of multiple genetic alterations leading to oncogene overexpression and tumor suppressor loss. Epigenetic alterations as a distinct and crucial mechanism to silence a variety of methylated tissue-specific and imprinted genes, have been extensively studied in gastric carcinoma and play important roles in gastric carcinogenesis. This review will briefly discuss the basic aspects of DNA methylation and CpG island methylation, in particular the epigenetic alterations of certain critical genes implicated in gastric carcinogenesis and its relevance of clinical implications.

Original language	English (US)
Pages (from-to)	247-254
Number of pages	8
Journal	Cell Research
Volume	15
Issue number	4
DOIs	https://doi.org/10.1038/sj.cr.7290293
State	Published - 2005

Keywords

Adenocarcinoma
Chronic gastritis
Dysplasia/adenoma
Epigenetic alterations
Gastric carcinogenesis
Intestinal metaplasia

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/sj.cr.7290293

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AB - Gastric cancer is believed to result in part from the accumulation of multiple genetic alterations leading to oncogene overexpression and tumor suppressor loss. Epigenetic alterations as a distinct and crucial mechanism to silence a variety of methylated tissue-specific and imprinted genes, have been extensively studied in gastric carcinoma and play important roles in gastric carcinogenesis. This review will briefly discuss the basic aspects of DNA methylation and CpG island methylation, in particular the epigenetic alterations of certain critical genes implicated in gastric carcinogenesis and its relevance of clinical implications.

KW - Adenocarcinoma

KW - Chronic gastritis

KW - Dysplasia/adenoma

KW - Epigenetic alterations

KW - Gastric carcinogenesis

KW - Intestinal metaplasia

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Epigenetic alterations in gastric carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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