Epidural narcotics in volunteers: Sensitivity to pain and to carbon dioxide

P. R. Bromage, E. Camporesi, J. Leslie

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Tolerance to pain and sensitivity to rising concentrations of inhaled carbon dioxide were measured before and after administration of methadone, 5 mg, or hydromorphone, 0.5 mg, by the intravenous route and by epidural injection in the lumbar or upper thoracic region in 5 subjects. Tolerance to periosteal pressure, cutaneous electrical stimulation and the cold pressor response to ice-water immersion were measured in both upper and lower limbs. Tolerance to all three pain modalities were greater in the epidural 'blocked' limbs than in the 'unblocked' limbs or after intravenous administration, and this difference was sustained after a second injection of narcotic. Sensitivity to carbon dioxide was less depressed by epidural narcotic than by intravenous administration; however, after a second dose of narcotic, depression of CO2 sensitivity by epidural injection was comparable to that produced by intravenous injection. These observations support the hypothesis that epidural narcotics have a segmental action as well as a systemic effect, and that both actions are dose-dependent.

Original languageEnglish (US)
Pages (from-to)145-160
Number of pages16
JournalPain
Volume9
Issue number2
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Narcotics
Carbon Dioxide
Volunteers
Epidural Injections
Pain
Intravenous Administration
Extremities
Hydromorphone
Methadone
Ice
Immersion
Intravenous Injections
Electric Stimulation
Lower Extremity
Thorax
Pressure
Skin
Injections
Water

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

Cite this

Epidural narcotics in volunteers : Sensitivity to pain and to carbon dioxide. / Bromage, P. R.; Camporesi, E.; Leslie, J.

In: Pain, Vol. 9, No. 2, 1980, p. 145-160.

Research output: Contribution to journalArticle

Bromage, P. R. ; Camporesi, E. ; Leslie, J. / Epidural narcotics in volunteers : Sensitivity to pain and to carbon dioxide. In: Pain. 1980 ; Vol. 9, No. 2. pp. 145-160.
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