Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells

Rebecca S. Bahn; K. V. Speeg; Mario Ascoli; David Rabin

doi:10.1210/endo-107-6-2121

Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells

Rebecca S. Bahn, K. V. Speeg, Mario Ascoli, David Rabin

Endocrinology, Diabetes, Metabolism, and Nutrition

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Abstract

Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Stimulation occurs in a time and dose-dependent manner. In addition, EGF increases [¹⁴C]-acetate incorporation into [¹⁴C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis.

Original language	English (US)
Pages (from-to)	2121-2123
Number of pages	3
Journal	Endocrinology
Volume	107
Issue number	6
DOIs	https://doi.org/10.1210/endo-107-6-2121
State	Published - Dec 1980

ASJC Scopus subject areas

Endocrinology

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title = "Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells",

abstract = "Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Stimulation occurs in a time and dose-dependent manner. In addition, EGF increases [14C]-acetate incorporation into [14C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis.",

author = "Bahn, {Rebecca S.} and Speeg, {K. V.} and Mario Ascoli and David Rabin",

year = "1980",

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AU - Bahn, Rebecca S.

AU - Speeg, K. V.

AU - Ascoli, Mario

AU - Rabin, David

PY - 1980/12

Y1 - 1980/12

N2 - Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Stimulation occurs in a time and dose-dependent manner. In addition, EGF increases [14C]-acetate incorporation into [14C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis.

AB - Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Stimulation occurs in a time and dose-dependent manner. In addition, EGF increases [14C]-acetate incorporation into [14C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis.

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Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells

Abstract

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