TY - JOUR
T1 - Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells
AU - Armstrong, Deborah K.
AU - Kaufmann, Scott H.
AU - Ottaviano, Yvonne L.
AU - Furuya, Yuzo
AU - Buckley, Julie A.
AU - Isaacs, John T.
AU - Davidson, Nancy E.
PY - 1994/10/15
Y1 - 1994/10/15
N2 - MDA-MB-468 human breast cancer cells lack estrogen receptors, overexpress epidermal growth factor (EGF) receptors, and are growth Inhibited by EGF. We show that treatment of MDA-MB-468 cells with EGF leads to inhibition of cell proliferation, fragmentation of DNA into nucleosomal oligomers, and the development of apoptotic morphology. This treatment is associated with increased expression of c-myc, c-fos, jun family members, and transforming growth factor β1 mRNA and with partial proteolytic cleavage of poly(ADP-ribose) polymerase and lamin B. The observation that EGF can mediate apoptosis in EGF receptor-over-expressing cells has important implications for clinical efforts directed at the EGF receptor.
AB - MDA-MB-468 human breast cancer cells lack estrogen receptors, overexpress epidermal growth factor (EGF) receptors, and are growth Inhibited by EGF. We show that treatment of MDA-MB-468 cells with EGF leads to inhibition of cell proliferation, fragmentation of DNA into nucleosomal oligomers, and the development of apoptotic morphology. This treatment is associated with increased expression of c-myc, c-fos, jun family members, and transforming growth factor β1 mRNA and with partial proteolytic cleavage of poly(ADP-ribose) polymerase and lamin B. The observation that EGF can mediate apoptosis in EGF receptor-over-expressing cells has important implications for clinical efforts directed at the EGF receptor.
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M3 - Article
C2 - 7923154
AN - SCOPUS:0027986676
VL - 54
SP - 5280
EP - 5283
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 20
ER -