Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells

Deborah K. Armstrong, Scott H Kaufmann, Yvonne L. Ottaviano, Yuzo Furuya, Julie A. Buckley, John T. Isaacs, Nancy E. Davidson

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153 Scopus citations

Abstract

MDA-MB-468 human breast cancer cells lack estrogen receptors, overexpress epidermal growth factor (EGF) receptors, and are growth inhibited by EGF. We show that treatment of MDA-MB-468 cells with EGF leads to inhibition of cell proliferation, fragmentation of DNA into nucleosomal oligomers, and the development of apoptotic morphology. This treatment is associated with increased expression of c-myc, c-fos, jun family members, and transforming growth factor β1 mRNA and with partial proteolytic cleavage of poly(ADP- ribose) polymerase and lamin B. The observation that EGF can mediate apoptosis in EGF receptor-overexpressing cells has important implications for clinical efforts directed at the EGF receptor.

Original languageEnglish (US)
Pages (from-to)5280-5283
Number of pages4
JournalCancer Research
Volume54
Issue number20
StatePublished - Oct 15 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Armstrong, D. K., Kaufmann, S. H., Ottaviano, Y. L., Furuya, Y., Buckley, J. A., Isaacs, J. T., & Davidson, N. E. (1994). Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Research, 54(20), 5280-5283.