Epidemiology of venous thromboembolism

John A. Heit

Research output: Contribution to journalArticle

269 Citations (Scopus)

Abstract

Thrombosis can affect any venous circulation. Venous thromboembolism (VTE) includes deep-vein thrombosis of the leg or pelvis, and its complication, pulmonary embolism. VTE is a fairly common disease, particularly in older age, and is associated with reduced survival, substantial health-care costs, and a high rate of recurrence. VTE is a complex (multifactorial) disease, involving interactions between acquired or inherited predispositions to thrombosis and various risk factors. Major risk factors for incident VTE include hospitalization for surgery or acute illness, active cancer, neurological disease with leg paresis, nursing-home confinement, trauma or fracture, superficial vein thrombosis, and - in women - pregnancy and puerperium, oral contraception, and hormone therapy. Although independent risk factors for incident VTE and predictors of VTE recurrence have been identified, and effective primary and secondary prophylaxis is available, the occurrence of VTE seems to be fairly constant, or even increasing.

Original languageEnglish (US)
Pages (from-to)464-474
Number of pages11
JournalNature Reviews Cardiology
Volume12
Issue number8
DOIs
StatePublished - Aug 28 2015

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Venous Thromboembolism
Epidemiology
Thrombosis
Leg
Recurrence
Paresis
Nursing Homes
Pelvis
Contraception
Pulmonary Embolism
Venous Thrombosis
Health Care Costs
Postpartum Period
Veins
Hospitalization
Hormones
Pregnancy
Survival
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Epidemiology of venous thromboembolism. / Heit, John A.

In: Nature Reviews Cardiology, Vol. 12, No. 8, 28.08.2015, p. 464-474.

Research output: Contribution to journalArticle

Heit, John A. / Epidemiology of venous thromboembolism. In: Nature Reviews Cardiology. 2015 ; Vol. 12, No. 8. pp. 464-474.
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