Epidemiology of sarcopenia

L. Joseph Melton, Sundeep Khosla, Cynthia Crowson, Michael K. O'Connor, W. Michael O'Fallon, B. Lawrence Riggs

Research output: Contribution to journalArticle

349 Citations (Scopus)

Abstract

OBJECTIVES: To examine patterns of muscle mass change with aging and to estimate the prevalence of sarcopenia. DESIGN: Cross-sectional survey. SETTING: Population-based study in Rochester, Minnesota. PARTICIPANTS: Age- stratified sample of men and women from the community. MEASUREMENTS: Muscle mass estimated from total body scans by dual-energy X-ray absorptiometry. Sarcopenia was defined as muscle mass more than 2 standard deviations below the sex-specific young-normal mean. RESULTS: Total lean body mass (exclusive of bone) and total skeletal muscle mass both were greater in men than women and declined linearly with age as judged from these cross-sectional data. Adjustment for height reduced the gender difference. The age- and sex- adjusted prevalence of sarcopenia varied from 6 to 15% among subjects 65 years of age or over, depending on the muscle mass parameter that was evaluated, but prevalence rates were quite sensitive to the normal values used to define cutoff levels. Subjects with sarcopenia appeared to have more physical limitations than the others. CONCLUSIONS: Late in life, a substantial portion of the population reaches low levels of muscle mass that are associated with increased physical disability. However, additional efforts are needed to validate an operational definition of sarcopenia.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalJournal of the American Geriatrics Society
Volume48
Issue number6
StatePublished - Jun 2000

Fingerprint

Sarcopenia
Epidemiology
Muscles
Paraphilic Disorders
Photon Absorptiometry
Population
Reference Values
Skeletal Muscle
Cross-Sectional Studies
Bone and Bones

Keywords

  • Aging
  • Epidemiology
  • Lean body mass
  • Prevalence
  • Sarcopenia

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Melton, L. J., Khosla, S., Crowson, C., O'Connor, M. K., O'Fallon, W. M., & Riggs, B. L. (2000). Epidemiology of sarcopenia. Journal of the American Geriatrics Society, 48(6), 625-630.

Epidemiology of sarcopenia. / Melton, L. Joseph; Khosla, Sundeep; Crowson, Cynthia; O'Connor, Michael K.; O'Fallon, W. Michael; Riggs, B. Lawrence.

In: Journal of the American Geriatrics Society, Vol. 48, No. 6, 06.2000, p. 625-630.

Research output: Contribution to journalArticle

Melton, LJ, Khosla, S, Crowson, C, O'Connor, MK, O'Fallon, WM & Riggs, BL 2000, 'Epidemiology of sarcopenia', Journal of the American Geriatrics Society, vol. 48, no. 6, pp. 625-630.
Melton LJ, Khosla S, Crowson C, O'Connor MK, O'Fallon WM, Riggs BL. Epidemiology of sarcopenia. Journal of the American Geriatrics Society. 2000 Jun;48(6):625-630.
Melton, L. Joseph ; Khosla, Sundeep ; Crowson, Cynthia ; O'Connor, Michael K. ; O'Fallon, W. Michael ; Riggs, B. Lawrence. / Epidemiology of sarcopenia. In: Journal of the American Geriatrics Society. 2000 ; Vol. 48, No. 6. pp. 625-630.
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